MedKoo Cat#: 564462 | Name: E1231
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

E1231 is a SIRT1 activator which protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.

Chemical Structure

E1231
E1231
CAS#1031195-19-3

Theoretical Analysis

MedKoo Cat#: 564462

Name: E1231

CAS#: 1031195-19-3

Chemical Formula: C21H21N3O3

Exact Mass: 363.1583

Molecular Weight: 363.42

Elemental Analysis: C, 69.41; H, 5.82; N, 11.56; O, 13.21

Price and Availability

Size Price Availability Quantity
100mg USD 750.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 5,250.00 2 Weeks
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Related CAS #
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Synonym
E-1231; E 1231; E1231
IUPAC/Chemical Name
1-(4-(2-(5-Methylfuran-2-yl)quinoline-4-carbonyl)piperazin-1-yl)ethan-1-one
InChi Key
ZQJTYRXKAZFWPK-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H21N3O3/c1-14-7-8-20(27-14)19-13-17(16-5-3-4-6-18(16)22-19)21(26)24-11-9-23(10-12-24)15(2)25/h3-8,13H,9-12H2,1-2H3
SMILES Code
CC(N1CCN(C(C2=CC(C3=CC=C(C)O3)=NC4=CC=CC=C24)=O)CC1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 363.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Feng T, Liu P, Wang X, Luo J, Zuo X, Jiang X, Liu C, Li Y, Li N, Chen M, Zhu N, Han X, Liu C, Xu Y, Si S. SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression. Atherosclerosis. 2018 Jul;274:172-181. doi: 10.1016/j.atherosclerosis.2018.04.039. Epub 2018 Apr 30. PubMed PMID: 29787963.