Synonym
α-hydroxyscopolamine, Anisodine, Daturamine
IUPAC/Chemical Name
Benzeneacetic acid, alpha-hydroxy-alpha-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl ester, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))-
InChi Key
JEJREKXHLFEVHN-VJDHNPKBSA-N
InChi Code
1S/C17H21NO5/c1-18-12-7-11(8-13(18)15-14(12)23-15)22-16(20)17(21,9-19)10-5-3-2-4-6-10/h2-6,11-15,19,21H,7-9H2,1H3/t11-,12-,13+,14-,15+,17-/m1/s1
SMILES Code
O1[C@H]2[C@@H]1[C@@H]1C[C@@H](C[C@@H]2N1C)OC([C@@](c1ccccc1)(O)CO)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
319.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Chen D, Peng C, Xie X, Chen Q, Liu H, Zhang S, Wan F, Ao H. Low Dose of Anisodine Hydrobromide Induced Neuroprotective Effects in Chronic Cerebral Hypoperfusion Rats. CNS Neurol Disord Drug Targets. 2017;16(10):1111-1119. doi: 10.2174/1871527316666171026114043. PubMed PMID: 29076436.
2: Wang Q, Gao S, Luo Y, Kang QY. Compound anisodine affects the proliferation and calcium overload of hypoxia-induced rat retinal progenitor cells and brain neural stem cells via the p-ERK1/2/HIF-1α/VEGF pathway. Exp Ther Med. 2017 Jul;14(1):600-608. doi: 10.3892/etm.2017.4528. Epub 2017 May 31. PubMed PMID: 28672973; PubMed Central PMCID: PMC5488403.
3: Liu WD, Chen LL, Shen CY, Jiang LB. Neuroprotective Effect of Compound Anisodine in a Mouse Model with Chronic Ocular Hypertension. Chin Med J (Engl). 2015 Oct 5;128(19):2652-7. doi: 10.4103/0366-6999.166043. PubMed PMID: 26415805; PubMed Central PMCID: PMC4736849.
4: Tian F, Li C, Wang X, Ren S, Li N, Liu Q, Zhou S, Lu Y, Zhao D, Chen X. Comparative study on pharmacokinetics of a series of anticholinergics, atropine, anisodamine, anisodine, scopolamine and tiotropium in rats. Eur J Drug Metab Pharmacokinet. 2015 Sep;40(3):245-53. doi: 10.1007/s13318-014-0192-y. Epub 2014 Apr 20. PubMed PMID: 24748278.
