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MedKoo Cat#: 584669 | Name: Majucin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Majucin is a sesquiterpene derived from Illicium sp. that possess complex caged chemical architecture and remarkable neurotrophic activities with potential activity against neurodegenerative diseases.

Chemical Structure

Majucin
Majucin
CAS#114687-97-7

Theoretical Analysis

MedKoo Cat#: 584669

Name: Majucin

CAS#: 114687-97-7

Chemical Formula: C15H20O8

Exact Mass: 328.1158

Molecular Weight: 328.32

Elemental Analysis: C, 54.88; H, 6.14; O, 38.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Majucin
IUPAC/Chemical Name
4,7a-Methano-3H,7aH-cyclopenta(e)furo(3,4-c)oxocin-3,6(7H)-dione, octahydro-3a,7,10,10a-tetrahydroxy-8,10b-dimethyl-, (3aR-(3a-alpha,4-alpha,7-beta,7a-alpha,8-beta,10-alpha,10a-alpha,10b-alpha))-
InChi Key
VXDVFPLMCHUTNP-KXGILDKWSA-N
InChi Code
InChI=1S/C15H20O8/c1-6-3-7(16)15(21)12(2)5-22-11(19)14(12,20)8-4-13(6,15)9(17)10(18)23-8/h6-9,16-17,20-21H,3-5H2,1-2H3/t6-,7-,8-,9+,12-,13+,14-,15+/m1/s1
SMILES Code
O=C1OC[C@]([C@]2(O)[C@@]3([C@H](C)C[C@H]2O)[C@H]4O)(C)[C@@]1(O)[C@](C3)([H])OC4=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 328.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Condakes ML, Hung K, Harwood SJ, Maimone TJ. Total Syntheses of (-)-Majucin and (-)-Jiadifenoxolane A, Complex Majucin-Type Illicium Sesquiterpenes. J Am Chem Soc. 2017 Dec 13;139(49):17783-17786. doi: 10.1021/jacs.7b11493. Epub 2017 Nov 26. PubMed PMID: 29148748; PubMed Central PMCID: PMC5729088. 2: Trzoss L, Xu J, Lacoske MH, Theodorakis EA. Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation. Beilstein J Org Chem. 2013 Jun 12;9:1135-40. doi: 10.3762/bjoc.9.126. Print 2013. PubMed PMID: 23843905; PubMed Central PMCID: PMC3701413. 3: Yokoyama R, Huang JM, Yang CS, Fukuyama Y. New seco-prezizaane-type sesquiterpenes, jiadifenin with neurotrophic activity and 1,2-dehydroneomajucin from Illicium jiadifengpi. J Nat Prod. 2002 Apr;65(4):527-31. PubMed PMID: 11975494. 4: Trzoss L, Xu J, Lacoske MH, Mobley WC, Theodorakis EA. Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies. Chemistry. 2013 May 10;19(20):6398-408. doi: 10.1002/chem.201300198. Epub 2013 Mar 22. PubMed PMID: 23526661; PubMed Central PMCID: PMC3875175. 5: Ma HJ, Ma CH, Huang JM. [Two new sesquiterpene lactones from the pericarp of Illicium macranthum]. Yao Xue Xue Bao. 2010 Mar;45(3):330-3. Chinese. PubMed PMID: 21351509.