LY 227942 | CAS#116817-14-2

MedKoo Cat#: 529173 | Name: LY 227942

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY 227942 is a bioactive chemical.

Chemical Structure

LY 227942

CAS#116817-14-2

Theoretical Analysis

MedKoo Cat#: 529173

Name: LY 227942

CAS#: 116817-14-2

Chemical Formula: C20H21NO5S

Exact Mass: 387.1140

Molecular Weight: 387.45

Elemental Analysis: C, 62.00; H, 5.46; N, 3.62; O, 20.65; S, 8.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

LY 227942

IUPAC/Chemical Name

2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, ethanedioate (1:1)

InChi Key

NMLRFGBDXFMJJM-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H19NOS.C2H2O4/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;3-1(4)2(5)6/h2-10,13,17,19H,11-12H2,1H3;(H,3,4)(H,5,6)

SMILES Code

CNCCC(OC1=C2C=CC=CC2=CC=C1)C3=CC=CS3.O=C(O)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 387.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yassin M, Oron A, Robinson D. Effect of adding medical cannabis to analgesic treatment in patients with low back pain related to fibromyalgia: an observational cross-over single centre study. Clin Exp Rheumatol. 2018 Oct 30. [Epub ahead of print] PubMed PMID: 30418116. 2: Yamashita T, Tsuda M, Tozaki-Saitoh H, Inoue K. [Green Pharma: A New Strategy for Drug Discovery in Academia by Targeting Glial Cells and ATP Receptors]. Yakugaku Zasshi. 2018;138(8):1027-1031. doi: 10.1248/yakushi.17-00211-1. Review. Japanese. PubMed PMID: 30068843. 3: Hu D, Wurster S. Hyponatremia Induced by Duloxetine: A Case Report. Consult Pharm. 2018 Aug 1;33(8):446-449. doi: 10.4140/TCP.n.2018.446. PubMed PMID: 30068437. 4: Fava GA, Benasi G, Lucente M, Offidani E, Cosci F, Guidi J. Withdrawal Symptoms after Serotonin-Noradrenaline Reuptake Inhibitor Discontinuation: Systematic Review. Psychother Psychosom. 2018;87(4):195-203. doi: 10.1159/000491524. Epub 2018 Jul 17. Review. PubMed PMID: 30016772. 5: Kim EJ, Felsovalyi K, Young LM, Shmelkov SV, Grunebaum MF, Cardozo T. Molecular basis of atypicality of bupropion inferred from its receptor engagement in nervous system tissues. Psychopharmacology (Berl). 2018 Sep;235(9):2643-2650. doi: 10.1007/s00213-018-4958-9. Epub 2018 Jul 1. PubMed PMID: 29961917; PubMed Central PMCID: PMC6132670. 6: Guo MY, Etminan M, Procyshyn RM, Kim DD, Samii A, Kezouh A, Carleton BC. Association of Antidepressant Use With Drug-Related Extrapyramidal Symptoms: A Pharmacoepidemiological Study. J Clin Psychopharmacol. 2018 Aug;38(4):349-356. doi: 10.1097/JCP.0000000000000911. PubMed PMID: 29901567. 7: Mizutani H, Sakakibara F, Komuro M, Sasaki E. TAS-303, a Novel Selective Norepinephrine Reuptake Inhibitor that Increases Urethral Pressure in Rats, Indicating Its Potential as a Therapeutic Agent for Stress Urinary Incontinence. J Pharmacol Exp Ther. 2018 Aug;366(2):322-331. doi: 10.1124/jpet.118.248039. Epub 2018 Jun 6. PubMed PMID: 29875227. 8: Tawfik MK, Helmy SA, Badran DI, Zaitone SA. Neuroprotective effect of duloxetine in a mouse model of diabetic neuropathy: Role of glia suppressing mechanisms. Life Sci. 2018 Jul 15;205:113-124. doi: 10.1016/j.lfs.2018.05.025. Epub 2018 May 12. PubMed PMID: 29763613. 9: Balaha M, Kandeel S, Kabel A. Phloretin either alone or in combination with duloxetine alleviates the STZ-induced diabetic neuropathy in rats. Biomed Pharmacother. 2018 May;101:821-832. doi: 10.1016/j.biopha.2018.02.135. Epub 2018 Mar 22. PubMed PMID: 29635891. 10: Cozart B, Diaz Vera J, Denham JD, Whiting WL. Treatment of Depression With Duloxetine in Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes. Clin Neuropharmacol. 2018 May/Jun;41(3):103-105. doi: 10.1097/WNF.0000000000000277. PubMed PMID: 29596118. 11: Siddiqui SH, Memon NA, Shanker R. Drug-induced movement disorder and confusion associated with duloxetine. BMJ Case Rep. 2018 Mar 28;2018. pii: bcr-2016-216746. doi: 10.1136/bcr-2016-216746. PubMed PMID: 29592972. 12: Li X, Zhu L, Zhou C, Liu J, Du H, Wang C, Fang S. Efficacy and tolerability of short-term duloxetine treatment in adults with generalized anxiety disorder: A meta-analysis. PLoS One. 2018 Mar 20;13(3):e0194501. doi: 10.1371/journal.pone.0194501. eCollection 2018. PubMed PMID: 29558528; PubMed Central PMCID: PMC5860757. 13: Kiso T, Moriyama A, Furutani M, Matsuda R, Funatsu Y. Effects of pregabalin and duloxetine on neurotransmitters in the dorsal horn of the spinal cord in a rat model of fibromyalgia. Eur J Pharmacol. 2018 May 15;827:117-124. doi: 10.1016/j.ejphar.2018.03.011. Epub 2018 Mar 9. PubMed PMID: 29530591. 14: Welsch P, Üçeyler N, Klose P, Walitt B, Häuser W. Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia. Cochrane Database Syst Rev. 2018 Feb 28;2:CD010292. doi: 10.1002/14651858.CD010292.pub2. Review. PubMed PMID: 29489029; PubMed Central PMCID: PMC5846183. 15: Thorpe J, Shum B, Moore RA, Wiffen PJ, Gilron I. Combination pharmacotherapy for the treatment of fibromyalgia in adults. Cochrane Database Syst Rev. 2018 Feb 19;2:CD010585. doi: 10.1002/14651858.CD010585.pub2. Review. PubMed PMID: 29457627. 16: Minguez L, Bureau R, Halm-Lemeille MP. Joint effects of nine antidepressants on Raphidocelis subcapitata and Skeletonema marinoi: A matter of amine functional groups. Aquat Toxicol. 2018 Mar;196:117-123. doi: 10.1016/j.aquatox.2018.01.015. Epub 2018 Jan 31. PubMed PMID: 29367071. 17: Dunlop BW, Cole SP, Nemeroff CB, Mayberg HS, Craighead WE. Differential change on depressive symptom factors with antidepressant medication and cognitive behavior therapy for major depressive disorder. J Affect Disord. 2018 Mar 15;229:111-119. doi: 10.1016/j.jad.2017.12.035. Epub 2017 Dec 27. PubMed PMID: 29306690; PubMed Central PMCID: PMC5807140. 18: Masuda R, Ajimi J, Murata T. Pharmacotherapy for Neuropathic Pain in Japan. J Nippon Med Sch. 2017;84(6):258-267. doi: 10.1272/jnms.84.258. Review. PubMed PMID: 29279555. 19: Revol R, Rault C, Polard E, Bellet F, Guy C. [Hyponatremia associated with SSRI/NRSI: Descriptive and comparative epidemiological study of the incidence rates of the notified cases from the data of the French National Pharmacovigilance Database and the French National Health Insurance]. Encephale. 2018 Jun;44(3):291-296. doi: 10.1016/j.encep.2017.09.003. Epub 2017 Dec 14. French. PubMed PMID: 29248119. 20: Nedahl M, Johansen SS, Linnet K. Reference Brain/Blood Concentrations of Citalopram, Duloxetine, Mirtazapine and Sertraline. J Anal Toxicol. 2018 Apr 1;42(3):149-156. doi: 10.1093/jat/bkx098. PubMed PMID: 29244076.