Neoambrosin | CAS# 18446-70-3 | Sesquiterpene Lactone

MedKoo Cat#: 573155 | Name: Neoambrosin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Neoambrosin is a sesquiterpene lactone which may show cytotoxic activity against multi-drug resistant cancer cells.

Chemical Structure

Neoambrosin

CAS#18446-70-3

Theoretical Analysis

MedKoo Cat#: 573155

Name: Neoambrosin

CAS#: 18446-70-3

Chemical Formula: C15H18O3

Exact Mass: 246.1256

Molecular Weight: 246.31

Elemental Analysis: C, 73.15; H, 7.37; O, 19.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Anhydrocoronopilin, Dehydrocoronopilin, Neoambrosin

IUPAC/Chemical Name

(3aS,6S,9aR,9bR)-6,9a-dimethyl-3-methylene-3,3a,4,5,6,8,9a,9b-octahydroazuleno[4,5-b]furan-2,9-dione

InChi Key

ALDYHLYMNPPSIB-XJFVKYJOSA-N

InChi Code

1S/C15H18O3/c1-8-4-5-10-9(2)14(17)18-13(10)15(3)11(8)6-7-12(15)16/h6,8,10,13H,2,4-5,7H2,1,3H3/t8-,10-,13+,15-/m0/s1

SMILES Code

C[C@H]1CC[C@@H]2[C@H]([C@]3(C1=CCC3=O)C)OC(=O)C2=C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 246.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Saeed M, Jacob S, Sandjo LP, Sugimoto Y, Khalid HE, Opatz T, Thines E, Efferth T. Cytotoxicity of the Sesquiterpene Lactones Neoambrosin and Damsin from Ambrosia maritima Against Multidrug-Resistant Cancer Cells. Front Pharmacol. 2015 Nov 9;6:267. doi: 10.3389/fphar.2015.00267. eCollection 2015. PubMed PMID: 26617519; PubMed Central PMCID: PMC4637410.