MedKoo Cat#: 564440 | Name: VH03-linker
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VH03-linker is a precursor of VHL ligand for PROTACs.

Chemical Structure

VH03-linker
VH03-linker
CAS#2064292-52-8

Theoretical Analysis

MedKoo Cat#: 564440

Name: VH03-linker

CAS#: 2064292-52-8

Chemical Formula: C32H50ClN5O8S

Exact Mass: 0.0000

Molecular Weight: 700.29

Elemental Analysis: C, 54.88; H, 7.20; Cl, 5.06; N, 10.00; O, 18.28; S, 4.58

Price and Availability

Size Price Availability Quantity
5mg USD 350.00
10mg USD 500.00
25mg USD 750.00
50mg USD 1,250.00
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Related CAS #
No Data
Synonym
VH-03 linker; VH 03 linker; VH03 linker; VH03-linker
IUPAC/Chemical Name
(2S,4R)-1-((S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide Hydrochloride
InChi Key
MSKHBFIXTCSMKP-DDLJGEAHSA-N
InChi Code
InChI=1S/C32H49N5O8S.ClH/c1-22-28(46-21-35-22)24-7-5-23(6-8-24)18-34-30(40)26-17-25(38)19-37(26)31(41)29(32(2,3)4)36-27(39)20-45-16-15-44-14-13-43-12-11-42-10-9-33;/h5-8,21,25-26,29,38H,9-20,33H2,1-4H3,(H,34,40)(H,36,39);1H/t25-,26+,29-;/m1./s1
SMILES Code
O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCN)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 700.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Jahn, S., Roggenbuck, D., Niemann, B., & Ward, E. S. (1995). Expression of monovalent fragments derived from a human IgM autoantibody in E. coli. The input of the somatically mutated CDR1/CDR2 and of the CDR3 into antigen binding specificity. Immunobiology, 193(5), 400-419.