Synonym
Tibenelast sodium
IUPAC/Chemical Name
Benzo(b)thiophene-2-carboxylic acid, 5,6-diethoxy-, sodium salt
InChi Key
ILEWAUWOUIHKID-UHFFFAOYSA-M
InChi Code
InChI=1S/C13H14O4S.Na/c1-3-16-9-5-8-6-12(13(14)15)18-11(8)7-10(9)17-4-2;/h5-7H,3-4H2,1-2H3,(H,14,15);/q;+1/p-1
SMILES Code
O=C(C1=CC2=CC(OCC)=C(OCC)C=C2S1)[O-].[Na+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
288.29
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Schwertschlag US, Cerimele BJ, McNay JL, Bowsher RR, Rowe H. Effect of tibenelast (a phosphodiesterase inhibitor) and theophylline on isoproterenol-stimulated heart rate, cyclic AMP and norepinephrine levels. Pharmacology. 1993;46(3):142-7. PubMed PMID: 8382824.
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4: Ho PP, Wang LY, Towner RD, Hayes SJ, Pollock D, Bowling N, Wyss V, Panetta JA. Cardiovascular effect and stimulus-dependent inhibition of superoxide generation from human neutrophils by tibenelast, 5,6-diethoxybenzo(b)thiophene-2-carboxylic acid, sodium salt (LY186655). Biochem Pharmacol. 1990 Nov 1;40(9):2085-92. PubMed PMID: 2173601.
5: Peyton AL, Ziege EA. Determination of a potential antiasthmatic compound, tibenelast, and its application to phase I clinical trials. J Chromatogr. 1990 Aug 3;529(2):377-87. PubMed PMID: 2229256.
6: Ho PP, Bertsch B, Esterman M, Panetta JA. Tibenelast, 5,6-diethoxybenzo(B)thiophene-2-carboxylic acid, sodium salt (LY186655), is an orally active anti-asthma compound in the guinea pig. Life Sci. 1990;46(13):917-25. PubMed PMID: 2329918.
