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MedKoo Cat#: 564432 | Name: CX717

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CX717, also known as Ampakine, is a positive allosteric modulator of the AMPA receptor.

Chemical Structure

CX717
CX717
CAS#867276-98-0

Theoretical Analysis

MedKoo Cat#: 564432

Name: CX717

CAS#: 867276-98-0

Chemical Formula: C11H11N3O3

Exact Mass: 233.0800

Molecular Weight: 233.23

Elemental Analysis: C, 56.65; H, 4.75; N, 18.02; O, 20.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Ampakine CX-717; Ampakine CX 717; Ampakine CX717; CX-717; CX 717; CX717
IUPAC/Chemical Name
2,1,3-Benzoxadiazol-5-yl(morpholin-4-yl)methanone
InChi Key
KFRQROSRKSVROW-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H11N3O3/c15-11(14-3-5-16-6-4-14)8-1-2-9-10(7-8)13-17-12-9/h1-2,7H,3-6H2
SMILES Code
O=C(C1=CC2=NON=C2C=C1)N3CCOCC3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 233.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Purcell R, Lynch G, Gall C, Johnson S, Sheng Z, Stephen MR, Cook J, Garman RH, Jortner B, Bolon B, Radin D, Lippa A. Brain Vacuolation Resulting From Administration of the Type II Ampakine CX717 Is An Artifact Related to Molecular Structure and Chemical Reaction With Tissue Fixative Agents. Toxicol Sci. 2018 Apr 1;162(2):383-395. doi: 10.1093/toxsci/kfx277. PubMed PMID: 29253237. 2: Turner SM, ElMallah MK, Hoyt AK, Greer JJ, Fuller DD. Ampakine CX717 potentiates intermittent hypoxia-induced hypoglossal long-term facilitation. J Neurophysiol. 2016 Sep 1;116(3):1232-8. doi: 10.1152/jn.00210.2016. Epub 2016 Jun 15. PubMed PMID: 27306673; PubMed Central PMCID: PMC5018053. 3: Kara NZ, Flaisher-Grinberg S, Einat H. Partial effects of the AMPAkine CX717 in a strain specific battery of tests for manic-like behavior in black Swiss mice. Pharmacol Rep. 2015 Oct;67(5):928-33. doi: 10.1016/j.pharep.2015.02.008. Epub 2015 Mar 4. PubMed PMID: 26398387. 4: Ren J, Lenal F, Yang M, Ding X, Greer JJ. Coadministration of the AMPAKINE CX717 with propofol reduces respiratory depression and fatal apneas. Anesthesiology. 2013 Jun;118(6):1437-45. doi: 10.1097/ALN.0b013e318291079c. PubMed PMID: 23542802. 5: Ren J, Ding X, Greer JJ. Respiratory depression in rats induced by alcohol and barbiturate and rescue by ampakine CX717. J Appl Physiol (1985). 2012 Oct;113(7):1004-11. doi: 10.1152/japplphysiol.00752.2012. Epub 2012 Jul 26. PubMed PMID: 22837171; PubMed Central PMCID: PMC3487499. 6: Zheng Y, Balabhadrapatruni S, Masumura C, Darlington CL, Smith PF. Effects of the putative cognitive-enhancing ampakine, CX717, on attention and object recognition memory. Curr Alzheimer Res. 2011 Dec;8(8):876-82. PubMed PMID: 22171951. 7: Boyle J, Stanley N, James LM, Wright N, Johnsen S, Arbon EL, Dijk DJ. Acute sleep deprivation: the effects of the AMPAKINE compound CX717 on human cognitive performance, alertness and recovery sleep. J Psychopharmacol. 2012 Aug;26(8):1047-57. doi: 10.1177/0269881111405353. Epub 2011 Sep 22. PubMed PMID: 21940760. 8: Ren J, Ding X, Funk GD, Greer JJ. Ampakine CX717 protects against fentanyl-induced respiratory depression and lethal apnea in rats. Anesthesiology. 2009 Jun;110(6):1364-70. doi: 10.1097/ALN.0b013e31819faa2a. PubMed PMID: 19461299. 9: Hampson RE, España RA, Rogers GA, Porrino LJ, Deadwyler SA. Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717. Psychopharmacology (Berl). 2009 Jan;202(1-3):355-69. doi: 10.1007/s00213-008-1360-z. Epub 2008 Nov 5. PubMed PMID: 18985324; PubMed Central PMCID: PMC3107999. 10: Porrino LJ, Daunais JB, Rogers GA, Hampson RE, Deadwyler SA. Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates. PLoS Biol. 2005 Sep;3(9):e299. Epub 2005 Aug 23. PubMed PMID: 16104830; PubMed Central PMCID: PMC1188239.

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