Picobenzide | CAS#51832-87-2 | neuroleptic

MedKoo Cat#: 584665 | Name: Picobenzide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Picobenzide, also known as M-14012-4, is a neuroleptic agent.

Chemical Structure

Picobenzide

CAS#51832-87-2

Theoretical Analysis

MedKoo Cat#: 584665

Name: Picobenzide

CAS#: 51832-87-2

Chemical Formula: C15H16N2O

Exact Mass: 240.1263

Molecular Weight: 240.31

Elemental Analysis: C, 74.97; H, 6.71; N, 11.66; O, 6.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Picobenzide; M 14012-4; MA 14012

IUPAC/Chemical Name

3,5-Dimethyl-N-(4-pyridylmethyl)benzamide

InChi Key

JROSDBYIFZWPBP-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H16N2O/c1-11-7-12(2)9-14(8-11)15(18)17-10-13-3-5-16-6-4-13/h3-9H,10H2,1-2H3,(H,17,18)

SMILES Code

O=C(NCC1=CC=NC=C1)C2=CC(C)=CC(C)=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 240.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Calvo MV, Nalda MA, Lanao JM, Dominguez-Gil A, Carrasco S. Pharmacokinetics and initial distribution of a new neuroleptic agent picobenzide (M-14012-4). Int J Clin Pharmacol Ther Toxicol. 1985 May;23(5):233-7. PubMed PMID: 2861167. 2: Casais L, Colom A, Martín del Río MP, Vallejo M, Cuenca E. [Comparative study of the pharmacological activity of N-(4-picolyl)-3,5-dimethylbenzamide (M-14012-4) and its N-oxide metabolite (M-3312-4). New pharmacological aspects]. Arch Farmacol Toxicol. 1979 Dec;5(3):159-64. Spanish. PubMed PMID: 44673. 3: Casais PL, Chermat R, Cuenca E, Simón P. [Effect of N-(4-picolyl)-3,5 dimethylbenzamide (M-14012-4) on stereotyped behavior induced by apomorphine and amphetamine in the rat and mouse]. Arch Farmacol Toxicol. 1981 Apr;7(1):65-72. Spanish. PubMed PMID: 7198897. 4: Santos Buelga D, Mariño EL, Domínguez-Gil A. Study of the disposition kinetics of the N-oxide-derivative: a metabolite of picobenzide. Eur J Drug Metab Pharmacokinet. 1989 Jan-Mar;14(1):19-22. PubMed PMID: 2759130. 5: Nieto MJ, Hernandez Hernandez JM, Lanao JM, Fernández C, Domínguez-Gil A. Isolation and identification of the N-oxide metabolite of picobenzide in human urine. Eur J Drug Metab Pharmacokinet. 1986 Jan-Mar;11(1):23-7. PubMed PMID: 3720794. 6: Garrido J, Pérez Naranjo J, Martínez Roldán C. [Comparative study of the central effects of M-14012-A and SKF-525-A in rodents]. Arch Farmacol Toxicol. 1983 Aug;9(2):191-202. Spanish. PubMed PMID: 6660935. 7: Gradillas A, López B, Braña MF, Sancho I, Pérez-García C, Alguacil LF. Synthesis and biological activity of picobenzide (3,5-dimethyl-N-(pyridin-4-ylmethyl)benzamide) analogues as potential antipsychotic agents. Arzneimittelforschung. 2005;55(12):725-9. PubMed PMID: 16430025. 8: Santos Buelga D, Mariño EL, Dominguez-Gil A, Sanchen Perez A. Determination of N-oxide of picobenzide by differential pulse polarography. Farmaco Prat. 1983 Oct;38(10):376-82. PubMed PMID: 6653746. 9: Pacheco M, Vich JM, Huguet J, Doria A, García Calderón P, Nalda MA. [Effect of MA-14012 (Dosetil) on lymphocyte mitogenesis. In vitro study]. Rev Esp Anestesiol Reanim. 1984 Jan-Feb;31(1):6-8. Spanish. PubMed PMID: 6146998. 10: González González A, Ayllón Rojas P, Sanz Fernández F, Rodríguez Devesa D, Martínez Roldán C. [Pharmacokinetic study of the picobenzide endovenously administered (author's transl)]. Arch Farmacol Toxicol. 1980 Aug;6(2):179-86. Spanish. PubMed PMID: 7469499. 11: Artalejo AR, García AG, Montiel C, Sánchez-García P. A dopaminergic receptor modulates catecholamine release from the cat adrenal gland. J Physiol. 1985 May;362:359-68. PubMed PMID: 4020691; PubMed Central PMCID: PMC1192902. 12: Serrano MI, Gómez CS, Cuenca E. [Effect of N-(4-picolyl)-3,5 dimethylbenzamide on arterial pressure and heart rate in unanesthetized rats]. Arch Farmacol Toxicol. 1981 Apr;7(1):171-80. Spanish. PubMed PMID: 7325710. 13: Caputo O, Viola F, Grosa G, Rocco F, Biglino G. 'In vitro' metabolism of N-picolyl-3,5-dimethylbenzamides. Eur J Drug Metab Pharmacokinet. 1986 Apr-Jun;11(2):91-9. PubMed PMID: 3770019. 14: Garrido García J, Pérez Naranjo J, Martínez Roldán C. [Modification of the triphasic mortality curve of d-amphetamine]. Arch Farmacol Toxicol. 1982 Dec;8(3):185-8. Spanish. PubMed PMID: 7183249.

View History

Picenadol Free Base

MedKoo CAT#: 414935

CAS#: 79201-85-7 (free base)