MedKoo Cat#: 573154 | Name: Amcinafal

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amcinafal is a topical steroidal anti-inflammatory.

Chemical Structure

Amcinafal
Amcinafal
CAS#3924-70-7

Theoretical Analysis

MedKoo Cat#: 573154

Name: Amcinafal

CAS#: 3924-70-7

Chemical Formula: C26H35FO6

Exact Mass: 462.2418

Molecular Weight: 462.56

Elemental Analysis: C, 67.51; H, 7.63; F, 4.11; O, 20.75

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Synonym
Amcinafal, SQ-15102, triamcinolone pentanonide
IUPAC/Chemical Name
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16,17-((1-ethylpropylidene)bis(oxy))-, (11beta,16alpha)-
InChi Key
NSZFBGIRFCHKOE-LFZVSNMSSA-N
InChi Code
1S/C26H35FO6/c1-5-24(6-2)32-21-12-18-17-8-7-15-11-16(29)9-10-22(15,3)25(17,27)19(30)13-23(18,4)26(21,33-24)20(31)14-28/h9-11,17-19,21,28,30H,5-8,12-14H2,1-4H3/t17-,18-,19-,21+,22-,23-,25-,26+/m0/s1
SMILES Code
CCC1(O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@@]5([C@]4([C@H](C[C@@]3([C@@]2(O1)C(=O)CO)C)O)F)C)CC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 462.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nygaard U, Deleuran M, Vestergaard C. Emerging Treatment Options in Atopic Dermatitis: Topical Therapies. Dermatology. 2017;233(5):333-343. doi: 10.1159/000484407. Epub 2017 Dec 8. Review. PubMed PMID: 29216643. 2: Mayba JN, Gooderham MJ. Review of Atopic Dermatitis and Topical Therapies. J Cutan Med Surg. 2017 May/Jun;21(3):227-236. doi: 10.1177/1203475416685077. Epub 2016 Dec 27. Review. PubMed PMID: 28300440. 3: Casale R, Symeonidou Z, Bartolo M. Topical Treatments for Localized Neuropathic Pain. Curr Pain Headache Rep. 2017 Mar;21(3):15. doi: 10.1007/s11916-017-0615-y. Review. PubMed PMID: 28271334; PubMed Central PMCID: PMC5340828.