Galantide | CAS#138579-66-5 | antagonist

MedKoo Cat#: 584664 | Name: Galantide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Galantide blocks the galanin-mediated inhibition of glucose-induced insulin secretion.

Chemical Structure

Galantide

CAS#138579-66-5

Theoretical Analysis

MedKoo Cat#: 584664

Name: Galantide

CAS#: 138579-66-5

Chemical Formula: C104H151N25O26S

Exact Mass: 2198.0983

Molecular Weight: 2199.56

Elemental Analysis: C, 56.79; H, 6.92; N, 15.92; O, 18.91; S, 1.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Galantide; M15

IUPAC/Chemical Name

L-Methioninamide, glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-

InChi Key

TZOJVPDIYKRJSM-GKPUQKAJSA-N

InChi Code

InChI=1S/C104H151N25O26S/c1-54(2)39-70(91(142)113-52-87(139)129-37-20-27-80(129)103(154)120-69(33-35-82(107)134)93(144)119-68(32-34-81(106)133)94(145)124-76(44-61-23-16-13-17-24-61)99(150)123-74(43-60-21-14-12-15-22-60)92(143)112-51-86(138)116-71(40-55(3)4)95(146)118-67(89(109)140)36-38-156-11)121-96(147)72(41-56(5)6)122-98(149)75(45-62-28-30-64(132)31-29-62)117-85(137)50-111-90(141)58(9)114-102(153)79(53-130)127-100(151)78(47-83(108)135)125-97(148)73(42-57(7)8)126-104(155)88(59(10)131)128-101(152)77(115-84(136)48-105)46-63-49-110-66-26-19-18-25-65(63)66/h12-19,21-26,28-31,49,54-59,67-80,88,110,130-132H,20,27,32-48,50-53,105H2,1-11H3,(H2,106,133)(H2,107,134)(H2,108,135)(H2,109,140)(H,111,141)(H,112,143)(H,113,142)(H,114,153)(H,115,136)(H,116,138)(H,117,137)(H,118,146)(H,119,144)(H,120,154)(H,121,147)(H,122,149)(H,123,150)(H,124,145)(H,125,148)(H,126,155)(H,127,151)(H,128,152)/t58-,59+,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,88-/m0/s1

SMILES Code

CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@H]3N(C(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC4=CC=C(O)C=C4)NC(CNC([C@H](C)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@H](CC5=CNC6=C5C=CC=C6)NC(CN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC3)=O)=O)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 2,199.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Barreto SG, Carati CJ, Schloithe AC, Toouli J, Saccone GT. Octreotide negates the benefit of galantide when used in the treatment of caerulein-induced acute pancreatitis in mice. HPB (Oxford). 2010 Aug;12(6):403-11. doi: 10.1111/j.1477-2574.2010.00191.x. PubMed PMID: 20662791; PubMed Central PMCID: PMC3028581. 2: Ceresini G, Sgoifo A, Freddi M, Musso E, Parmigiani S, Del Rio G, Valenti G. Effects of galanin and the galanin receptor antagonist galantide on plasma catecholamine levels during a psychosocial stress stimulus in rats. Neuroendocrinology. 1998 Jan;67(1):67-72. PubMed PMID: 9485171. 3: Korolkiewicz R, Sliwiński W, Rekowski P, Halama-Borowiec A, Mucha P, Szczurowicz A, Korolkiewicz KZ. Galanin, galantide and galanin (1-14)-[alpha-aminobutyric acid8]-scyliorhinin-I: structure dependent effects on the rat isolated gastric fundus. Pharmacol Res. 1997 Jan;35(1):7-16. PubMed PMID: 9149310. 4: Bivalacqua TJ, Champion HC, Purohit SK, Murphy WA, Coy DH, Kadowitz PJ, Hellstrom WJ. Nitric oxide-mediated erectile effects of galantide but not galanin in vivo. Nitric Oxide. 2000 Apr;4(2):94-102. PubMed PMID: 10835289. 5: Korolkiewicz RP, Konstanski Z, Rekowski P, Szyk A, Ruczyński J, Dabrowski J, Ujda M, Korolkiewicz KZ, Petrusewicz J. Mechanism of the contractile effects of galantide and Galanin(1-14) [alpha-aminobutyric acid]scyliorhinin-I in rat isolated fundus strips. Med Sci Monit. 2002 Jan;8(1):BR19-23. PubMed PMID: 11782668. 6: Kozyrev N, Coolen LM. Activation of galanin and cholecystokinin receptors in the lumbosacral spinal cord is required for ejaculation in male rats. Eur J Neurosci. 2017 Mar;45(6):846-858. doi: 10.1111/ejn.13515. Epub 2017 Jan 24. PubMed PMID: 28002640. 7: Barreto SG, Carati CJ, Schloithe AC, Mathison R, Davison JS, Toouli J, Saccone GT. The efficacy of combining feG and galantide in mild caerulein-induced acute pancreatitis in mice. Peptides. 2010 Jun;31(6):1076-82. doi: 10.1016/j.peptides.2010.02.027. Epub 2010 Mar 7. PubMed PMID: 20214943. 8: Arletti R, Benelli A, Cavazzuti E, Bertolini A. Galantide improves social memory in rats. Pharmacol Res. 1997 Apr;35(4):317-9. PubMed PMID: 9264048. 9: Wodowska J, Ciosek J. Galanin and galanin-like peptide modulate vasopressin and oxytocin release in vitro: the role of galanin receptors. Neuropeptides. 2014 Dec;48(6):387-97. doi: 10.1016/j.npep.2014.10.005. Epub 2014 Nov 10. PubMed PMID: 25464889. 10: Tayh G, Ben Sallem R, Ben Yahia H, Gharsa H, Klibi N, Boudabous A, Ben Slama K. First Report of Extended-Spectrum β-Lactamases Among Clinical Isolates of Klebsiella pneumoniae in Gaza Strip, Palestine. Microb Drug Resist. 2017 Mar;23(2):169-176. doi: 10.1089/mdr.2016.0089. Epub 2016 Jun 13. PubMed PMID: 27294803. 11: Deecher DC, Odusan OO, Mufson EJ. Galanin receptors in human basal forebrain differ from receptors in the hypothalamus: characterization using [125I]galanin (porcine) and [125I]galantide. J Pharmacol Exp Ther. 1995 Nov;275(2):720-7. PubMed PMID: 7473159. 12: Yadav N, Gupta MN, Khare SK. Three phase partitioning and spectroscopic characterization of bioactive constituent from halophilic Bacillus subtilis EMB M15. Bioresour Technol. 2017 Oct;242:283-286. doi: 10.1016/j.biortech.2017.04.090. Epub 2017 Apr 26. PubMed PMID: 28478895. 13: Benelli A, Arletti R, Bertolini A, Menozzi B, Basaglia R, Poggioli R. Galantide stimulates sexual behaviour in male rats. Eur J Pharmacol. 1994 Aug 1;260(2-3):279-82. PubMed PMID: 7527345. 14: Sahu A, Xu B, Kalra SP. Role of galanin in stimulation of pituitary luteinizing hormone secretion as revealed by a specific receptor antagonist, galantide. Endocrinology. 1994 Feb;134(2):529-36. PubMed PMID: 7507825. 15: Bhandari M, Kawamoto M, Thomas AC, Barreto SG, Schloithe AC, Carati CJ, Toouli J, Saccone GT. Galanin receptor antagonist m35 but not m40 or c7 ameliorates cerulein-induced acute pancreatitis in mice. Pancreatology. 2010;10(6):682-8. doi: 10.1159/000314603. Epub 2011 Jan 18. PubMed PMID: 21242707. 16: Korolkiewicz R, Sliwiński W, Konstański Z, Rekowski P, Halama-Borowiec A, Szyk A, Emerich J, Korolkiewicz KZ. Pharmacological characterization of the contractile effects of galanin (1-29)-NH2, galantide and galanin (1-14)-(alpha-aminobutyric acid8)scyliorhinin-I in the rat gastric fundus. Fundam Clin Pharmacol. 1997;11(6):576-83. PubMed PMID: 9444526. 17: Lindskog S, Ahrén B, Land T, Langel U, Bartfai T. The novel high-affinity antagonist, galantide, blocks the galanin-mediated inhibition of glucose-induced insulin secretion. Eur J Pharmacol. 1992 Jan 14;210(2):183-8. PubMed PMID: 1376272. 18: Mulvaney JM, Merriam LA, Parsons RL. Galantide distinguishes putative subtypes of galanin receptors in mudpuppy parasympathetic neurons. Eur J Pharmacol. 1995 Dec 4;287(1):97-100. PubMed PMID: 8666034. 19: Lee SK, Choi D, Chon JW, Seo KH. Resistance of Strains Producing Extended-Spectrum β-Lactamases Among Salmonella from Duck Carcasses at Slaughterhouses in Three Major Provinces of South Korea. Foodborne Pathog Dis. 2016 Mar;13(3):135-41. doi: 10.1089/fpd.2015.2042. Epub 2016 Feb 17. PubMed PMID: 26885565. 20: Takahashi T, Belvisi MG, Barnes PJ. Modulation of neurotransmission in guinea-pig airways by galanin and the effect of a new antagonist galantide. Neuropeptides. 1994 Apr;26(4):245-51. PubMed PMID: 7518053.