MedKoo Cat#: 564419 | Name: MX106

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MX106 is a survivin inhibitor which induces degradation of XIAP and/or cIAP1, and suppresses genotoxic NF-kappaB activation.

Chemical Structure

MX106
MX106
CAS#2170836-81-2

Theoretical Analysis

MedKoo Cat#: 564419

Name: MX106

CAS#: 2170836-81-2

Chemical Formula: C25H30N2O2

Exact Mass: 390.2307

Molecular Weight: 390.53

Elemental Analysis: C, 76.89; H, 7.74; N, 7.17; O, 8.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MX-106; MX 106; MX106
IUPAC/Chemical Name
5-(((4-Isopropylbenzyl)oxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol
InChi Key
NNIPSBLMEGJOFO-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H30N2O2/c1-18(2)20-9-7-19(8-10-20)16-29-17-22-14-21(15-27-12-3-4-13-27)25(28)24-23(22)6-5-11-26-24/h5-11,14,18,28H,3-4,12-13,15-17H2,1-2H3
SMILES Code
OC1=C2N=CC=CC2=C(COCC3=CC=C(C(C)C)C=C3)C=C1CN4CCCC4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 390.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Xiao M, Xue Y, Wu Z, Lei ZN, Wang J, Chen ZS, Li W. Design, synthesis and biological evaluation of selective survivin inhibitors. J Biomed Res. 2018 Aug 31. doi: 10.7555/JBR.31.20160173. [Epub ahead of print] PubMed PMID: 30174320. 2: Wang W, Zhang B, Mani AM, Wu Z, Fan Y, Li W, Wu ZH. Survivin Inhibitors Mitigate Chemotherapeutic Resistance in Breast Cancer Cells by Suppressing Genotoxic Nuclear Factor-κB Activation. J Pharmacol Exp Ther. 2018 Jul;366(1):184-193. doi: 10.1124/jpet.118.249151. Epub 2018 May 7. PubMed PMID: 29735611; PubMed Central PMCID: PMC6038029.