Fenquizone | CAS#20287-37-0 | diuretic

MedKoo Cat#: 584662 | Name: Fenquizone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fenquizone is a diuretic.

Chemical Structure

Fenquizone

CAS#20287-37-0

Theoretical Analysis

MedKoo Cat#: 584662

Name: Fenquizone

CAS#: 20287-37-0

Chemical Formula: C21H29NO

Exact Mass: 311.2249

Molecular Weight: 311.47

Elemental Analysis: C, 80.98; H, 9.39; N, 4.50; O, 5.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Fenquizone; M.G. 13054

IUPAC/Chemical Name

2-Phenyl-6-sulfonamido-7-chloro-1,2,3,4-tetrahydro-4-quinazolidone

InChi Key

HXRPWNPBWOLFPN-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H29NO/c1-3-22(4-2)17-8-18-23-21-15-13-20(14-16-21)12-11-19-9-6-5-7-10-19/h5-7,9-10,13-16H,3-4,8,11-12,17-18H2,1-2H3

SMILES Code

CCN(CC)CCCOC1=CC=C(CCC2=CC=CC=C2)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 311.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Marzo A, Quadro G, Treffner E. Gas-liquid chromatographic evaluation of fenquizone in biological samples for pharmacokinetic investigations. J Chromatogr. 1983 Jan 14;272(1):95-102. PubMed PMID: 6841550. 2: Angelino PF, Alvino-Demartino A, Mappa R, Donati C. Double-blind crossover study of fenquizone compared to chlorthalidone in essential hypertension. Int J Clin Pharmacol Ther Toxicol. 1985 Sep;23(9):501-5. PubMed PMID: 3902676. 3: Costa FV, Borghi C, Boschi S, Mussi A, Ambrosioni E. Hemodynamic and humoral effects of chronic antihypertensive treatment with fenquizone: importance of aldosterone response. J Clin Pharmacol. 1990 Mar;30(3):254-61. PubMed PMID: 2179289. 4: Della Marchina MM, Renzi G, Serofilli S. [Diuretic therapy in the aged. A clinical comparison between two diuretic compounds]. Minerva Med. 1981 Jan 28;72(3):163-6. Italian. PubMed PMID: 7207841. 5: Ferrando C, Foy JM, Pratt CN, Purvis JR. On the pharmacological actions of a diuretic, fenquizone, with particular reference to its site of action. J Pharm Pharmacol. 1981 Apr;33(4):219-22. PubMed PMID: 6115903. 6: Pasotti C, Rossi R, Gandolfi P. [Fenquizone in the medium term treatment of essential hypertension. Double-blind comparison with chlorthalidone and placebo]. Minerva Med. 1981 Nov 17;72(46):3105-10. Italian. PubMed PMID: 7029355. 7: Cupisti A, Ciardella F, Morelli E, Dani L, Lupetti S, Luchi S, Meola M, Barsotti G. The effect of fenquizone on the urinary inhibitors of calcium oxalate urolithiasis. Contrib Nephrol. 1987;58:184-6. PubMed PMID: 3691123. 8: Maggi GC, Donati C, Gueli Alletti D. Single-dose pharmacokinetics of fenquizone in healthy volunteers. Arzneimittelforschung. 1985;35(6):994-8. PubMed PMID: 4026929. 9: Placidi GF, Fornaro P, Guarneri M. Autoradiographic distribution study of 14C-2-phenyl-6-sulfonamido-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone (fenquizone) in mice. Arzneimittelforschung. 1979;29(7):1005-8. PubMed PMID: 582990. 10: Bellini G, Battilana G, Carretta R, Bacci D, Fabris B, Menchini U. [Comparative studies of the effects of the diuretics, fenquizone and chlorthalidone, in arterial hypertension]. G Clin Med. 1981 Feb;62(2):119-28. Italian. PubMed PMID: 7239056. 11: Ceriani D, Di Giulio AM, Panelli M. Physiological disposition of a new diuretic compound, 2-phenyl-6-sulfonamido-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone (M.G. 13054 - fenquizone), in the dog. Farmaco Sci. 1976 May;31(5):379-87. PubMed PMID: 1269742. 12: Strocchi E, Malini PL, Montebugnoli L, Costa FV, Ambrosioni E. [Anti-hypertensive efficacy and metabolic effects of fenquizone after a year's treatment]. Cardiologia. 1982;27(4):325-33. Italian. PubMed PMID: 6927478. 13: Beermann B, Grind M. Clinical pharmacokinetics of some newer diuretics. Clin Pharmacokinet. 1987 Oct;13(4):254-66. Review. PubMed PMID: 3311532. 14: Tiberi F, Corinaldesi G. [Clinical trial of the activity and therapeutic effectiveness of 3 drugs with diuretic and antihypertensive action]. Minerva Med. 1981 Jan 21;72(2):95-100. Italian. PubMed PMID: 7007928. 15: Panelli M. [Determination of phenquizone in the urine]. Boll Chim Farm. 1974 Mar;113(3):175-8. Italian. PubMed PMID: 4845368.