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MedKoo Cat#: 573147 | Name: Anemonin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Anemonin is a furanone dimer found in the Buttercup (Ranunculaceae) family. Anemonin has been shown to regulate tyrosinase-related proteins and mRNA in human melanocytes and may be useful in attenuting osteoarthritis progression.

Chemical Structure

Anemonin
Anemonin
CAS#508-44-1

Theoretical Analysis

MedKoo Cat#: 573147

Name: Anemonin

CAS#: 508-44-1

Chemical Formula: C10H8O4

Exact Mass: 192.0423

Molecular Weight: 192.17

Elemental Analysis: C, 62.50; H, 4.20; O, 33.30

Price and Availability

Size Price Availability Quantity
10mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
Anemonin, Anemone camphor, Pulsatilla camphor
IUPAC/Chemical Name
(5S,6S)-1,7-dioxadispiro[4.0.46.25]dodeca-3,9-diene-2,8-dione
InChi Key
JLUQTCXCAFSSLD-NXEZZACHSA-N
InChi Code
1S/C10H8O4/c11-7-1-3-9(13-7)5-6-10(9)4-2-8(12)14-10/h1-4H,5-6H2/t9-,10-/m1/s1
SMILES Code
O=C1O[C@@]2(CC[C@@]23OC(=O)C=C3)C=C1
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 192.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Xia Q, Liu G, Zhang L, Xie B, Deng L. Anemonin suppresses sepsis-induced acute lung injury by inactivation of nuclear factor-kappa B and activation of nuclear factor erythroid 2-related factor-2/heme oxygenase-1 pathway. FASEB J. 2025 Jan 31;39(2):e70328. doi: 10.1096/fj.202401987RR. PMID: 39825692. 2: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. Pulsatilla. 2025 Jan 15. PMID: 29999784. 3: Sirak B, Aragaw M, Tadesse S. Ranunculin, Protoanemonin, and Anemonin: Pharmacological and Chemical Perspectives. Curr Med Chem. 2024 Feb 28. doi: 10.2174/0109298673294080240221115830. Epub ahead of print. PMID: 38425112. 4: Sirak B, Bizuneh GK, Imming P, Asres K. In vitro and in vivo antitrypanosomal activity of the fresh leaves of Ranunculus Multifidus Forsk and its major compound anemonin against Trypanosoma congolense field isolate. BMC Vet Res. 2024 Jan 27;20(1):32. doi: 10.1186/s12917-023-03856-1. PMID: 38279149; PMCID: PMC10821574. 5: Zhao L, Hu K, Liu W, Qi H, Li G, Chen J, Han L. Anemonin ameliorates human diploid fibroblasts 2BS and IMR90 cell senescence by PARP1-NAD+-SIRT1 signaling pathway. Arch Gerontol Geriatr. 2024 Feb;117:105255. doi: 10.1016/j.archger.2023.105255. Epub 2023 Oct 31. PMID: 37952424. 6: Liu D, Li L, Li Z. Anemonin inhibits sepsis-induced acute kidney injury via mitigating inflammation and oxidative stress. Biotechnol Appl Biochem. 2023 Dec;70(6):1983-2001. doi: 10.1002/bab.2504. Epub 2023 Aug 17. PMID: 37592376. 7: Pirvu LC, Neagu G, Albulescu A, Stefaniu A, Pintilie L. Potential Benefits of Dietary Plant Compounds on Normal and Tumor Brain Cells in Humans: In Silico and In Vitro Approaches. Int J Mol Sci. 2023 Apr 17;24(8):7404. doi: 10.3390/ijms24087404. PMID: 37108565; PMCID: PMC10139435. 8: Ma Z, Yu P, Li X, Dai F, Jiang H, Liu J. Anemonin reduces hydrogen peroxide- induced oxidative stress, inflammation and extracellular matrix degradation in nucleus pulposus cells by regulating NOX4/NF-κB signaling pathway. J Orthop Surg Res. 2023 Mar 11;18(1):189. doi: 10.1186/s13018-023-03679-8. PMID: 36899420; PMCID: PMC10007850. 9: Jiang L, Chi C, Yuan F, Lu M, Hu D, Wang L, Liu X. Anti-inflammatory effects of anemonin on acute ulcerative colitis via targeted regulation of protein kinase C-θ. Chin Med. 2022 Mar 28;17(1):39. doi: 10.1186/s13020-022-00599-3. PMID: 35346284; PMCID: PMC8962473. 10: Sirak B, Asres K, Hailu A, Dube M, Arnold N, Häberli C, Keiser J, Imming P. In Vitro Antileishmanial and Antischistosomal Activities of Anemonin Isolated from the Fresh Leaves of Ranunculus multifidus Forsk. Molecules. 2021 Dec 10;26(24):7473. doi: 10.3390/molecules26247473. PMID: 34946555; PMCID: PMC8703683. 11: Sirak B, Mann L, Richter A, Asres K, Imming P. In Vivo Antimalarial Activity of Leaf Extracts and a Major Compound Isolated from Ranunculus multifidus Forsk. Molecules. 2021 Oct 13;26(20):6179. doi: 10.3390/molecules26206179. PMID: 34684762; PMCID: PMC8537993. 12: Müller MB, Bertrams J, Stintzing FC. Stability of protoanemonin in plant extracts from Helleborus niger L. and Pulsatilla vulgaris Mill. J Pharm Biomed Anal. 2020 Sep 5;188:113370. doi: 10.1016/j.jpba.2020.113370. Epub 2020 May 20. PMID: 32497949. 13: Hou H, Peng Q, Wang S, Zhang Y, Cao J, Deng Y, Wang Y, Sun WC, Wang HB. Anemonin Attenuates RANKL-Induced Osteoclastogenesis and Ameliorates LPS-Induced Inflammatory Bone Loss in Mice via Modulation of NFATc1. Front Pharmacol. 2020 Feb 10;10:1696. doi: 10.3389/fphar.2019.01696. PMID: 32116686; PMCID: PMC7025528. 14: Qiao L, Liu Y, Li C, Ge J, Li T. Regulation of iRhom-2/Tumor Necrosis Factor-α Converting Enzyme Pathway and Oxidative Stress Protects the Renal Injury with Anemonin in Streptozotocin-Induced Diabetic Nephropathy Neonatal Rat Model. Pharmacology. 2019;104(5-6):258-266. doi: 10.1159/000501631. Epub 2019 Jul 25. Retraction in: Pharmacology. 2024;109(3):182. doi: 10.1159/000538990. PMID: 31344701. 15: Saidi R, Ghrab F, Kallel R, Feki AE, Boudawara T, Chesné C, Ammar E, Jarraya RM. Tunisian Clematis flammula Essential Oil Enhances Wound Healing: GC-MS Analysis, Biochemical and Histological Assessment. J Oleo Sci. 2018;67(11):1483-1499. doi: 10.5650/jos.ess18056. PMID: 30404969. 16: Neag T, Olah NK, Hanganu D, Benedec D, Pripon FF, Ardelean A, Toma CC. The anemonin content of four different Ranunculus species. Pak J Pharm Sci. 2018 Sep;31(5(Supplementary)):2027-2032. PMID: 30393208. 17: Saidi R, Khanous L, Khadim Allah S, Hamdi B, Ayadi A, Damak M, Hammami H, Mezghani-Jarraya R. Antifungal, molluscicidal and larvicidal assessment of anemonin and Clematis flammula L. extracts against mollusc Galba truncatula, intermediate host of Fasciola hepatica in Tunisia. Asian Pac J Trop Med. 2017 Oct;10(10):967-973. doi: 10.1016/j.apjtm.2017.09.008. Epub 2017 Sep 20. PMID: 29111192. 18: Wang Z, Huang J, Zhou S, Luo F, Xu W, Wang Q, Tan Q, Chen L, Wang J, Chen H, Chen L, Xie Y, Du X. Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL-1β/NF-κB pathway. J Cell Mol Med. 2017 Dec;21(12):3231-3243. doi: 10.1111/jcmm.13227. Epub 2017 Jun 23. PMID: 28643466; PMCID: PMC5706500. 19: Xiao K, Cao ST, Jiao le F, Lin FH, Wang L, Hu CH. Anemonin improves intestinal barrier restoration and influences TGF-β1 and EGFR signaling pathways in LPS-challenged piglets. Innate Immun. 2016 Jul;22(5):344-52. doi: 10.1177/1753425916648223. Epub 2016 May 12. PMID: 27189428. 20: Ning Y, Rao Y, Yu Z, Liang W, Li F. Skin permeation profile and anti- inflammatory effect of anemonin extracted from weilingxian. Pharmazie. 2016 Mar;71(3):134-8. PMID: 27183707.