Moprolol | CAS#5741-22-0 | beta-blocker

MedKoo Cat#: 584659 | Name: Moprolol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

(-)-Moprolol is beta-blocker & anti-hypertensive agent; (+)-Moprolol is inactive.

Chemical Structure

Moprolol

CAS#5741-22-0

Theoretical Analysis

MedKoo Cat#: 584659

Name: Moprolol

CAS#: 5741-22-0

Chemical Formula: C13H21NO3

Exact Mass: 239.1521

Molecular Weight: 239.32

Elemental Analysis: C, 65.25; H, 8.85; N, 5.85; O, 20.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Moprolol; M 66527; (+-)-Moprolol; dl-Moprolol

IUPAC/Chemical Name

1-(2-Methoxyphenoxy)-3-((1-methylethyl)amino)-2-propanol

InChi Key

LFTFGCDECFPSQD-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H21NO3/c1-10(2)14-8-11(15)9-17-13-7-5-4-6-12(13)16-3/h4-7,10-11,14-15H,8-9H2,1-3H3

SMILES Code

OC(CNC(C)C)COC1=CC=CC=C1OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 239.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rossetti L, Barbieri P, Velati P, Bujtar E, Orzalesi N. The efficacy of the combination of l-moprolol and dipivefrin in reducing the intraocular pressure in primary open-angle glaucoma or in ocular hypertension. Graefes Arch Clin Exp Ophthalmol. 1994 Nov;232(11):670-4. PubMed PMID: 7843592. 2: Porciatti F, Cerbai E, Masini I, Mugelli A. Electrophysiological evaluation of the beta-blocking properties and direct membrane effects of l-moprolol and its enantiomer d-moprolol. Arch Int Pharmacodyn Ther. 1989 May-Jun;299:200-9. PubMed PMID: 2570555. 3: Ghosh S, Bhaumik J, Banoth L, Banesh S, Banerjee UC. Chemoenzymatic Route for the Synthesis of (S)-Moprolol, a Potential β-Blocker. Chirality. 2016 Apr;28(4):313-8. doi: 10.1002/chir.22574. Epub 2016 Jan 28. PubMed PMID: 26821612. 4: Li F, Bi H, Côté M, Cooper S. Identification and determination of the enantiomers of moprolol and their metabolites in human urine by high-performance liquid chromatography and gas chromatography-mass spectrometry. J Chromatogr. 1993 Dec 22;622(2):187-95. PubMed PMID: 7908669. 5: Triulzi MO, Balice G, Gentile F, Rossini GL, Fattori CM. Tolerability of high doses of (-)-moprolol in healthy volunteers. Eur J Clin Pharmacol. 1982;22(4):377-8. PubMed PMID: 6125397. 6: Harvengt C, Desager JP. The pharmacokinetics of dl- and l-moprolol in the human. Int J Clin Pharmacol Ther Toxicol. 1982 Feb;20(2):57-61. PubMed PMID: 6120901. 7: el-Ashmawy MB, Lissavetzky J, Darias V, Martín-Herrera D. Synthesis and pharmacological study of a thiophene analogue of moprolol and related compounds. Arch Pharm (Weinheim). 1991 Jan;324(1):45-8. PubMed PMID: 1675047. 8: Merlo L, Brusoni B, Mussini E, Ghirardi P. [The cardiovascular effects of the optical isomers of 1-(0-methoxy-phenoxy-)-3-isopropylamino-2-propanolo-hydrochloride (moprolol)]. Boll Soc Ital Cardiol. 1980;25(8):955-61. Italian. PubMed PMID: 6116496. 9: Ghirardi P, Grosso F. Antihypertensive activity of (-) moprolol in man: double-blind comparison of enantiomers. J Cardiovasc Pharmacol. 1980 Jul-Aug;2(4):471-2. PubMed PMID: 6156344. 10: De Ambroggi L, Perotta GM, Satolli R, Lotto A. [Evaluation of the effects of a beta-blocking drug (moprolol) on hemodynamics and lesion potentials in acute myocardial infarct]. Boll Soc Ital Cardiol. 1977;22(8):1343-51. Italian. PubMed PMID: 36116. 11: White JD, Shaw S. A new catalyst for the asymmetric Henry reaction: synthesis of β-nitroethanols in high enantiomeric excess. Org Lett. 2012 Dec 21;14(24):6270-3. doi: 10.1021/ol3030023. Epub 2012 Nov 30. PubMed PMID: 23194499. 12: Alinovi A, Branchetti A, Barella PA. [Iatrogenic dermatoses caused by beta-blocking drugs]. G Ital Dermatol Venereol. 1983 Nov-Dec;118(6):341-8. Review. Italian. PubMed PMID: 6143722. 13: Duclos J, Kussaibi H, Pacault V, Roussel H, Sandid W, Janin A, Bertheau P. [A case of giant cell microscopic colitis?]. Ann Pathol. 2008 Dec;28(6):501-3. doi: 10.1016/j.annpat.2008.09.045. Epub 2008 Nov 17. French. PubMed PMID: 19084720. 14: Gianesello V, Brenn E, Figini G, Gazzaniga A. Determination by coupled high-performance liquid chromatography-gas chromatography of the beta-blocker levomoprolol in plasma following ophthalmic administration. J Chromatogr. 1989 Jul 7;473(2):343-52. PubMed PMID: 2570078. 15: Santambrogio R, Opocher E, Galeotti F, Montorsi M, Cucchiaro G, Gagliano G, Spina GP. [The hemodynamic effects on the portal system of levomoprolol and propranolol in rats with an enhanced adrenergic tonus]. Minerva Med. 1989 Aug;80(8):949-51. Italian. PubMed PMID: 2571957. 16: Pecori-Giraldi J, Virno M, Ciarnella A, Taverniti L. [The beta-blocker levomoprolol in the treatment of glaucoma]. Bull Mem Soc Fr Ophtalmol. 1985;96:433-6. French. PubMed PMID: 2861871. 17: Santambrogio R, Galeotti F, Opocher E, Cucchiaro G, Cornalba GP, Rota L, Ferrario M, Fumagalli U, Spina GP. [Role of beta blockers in preventing hemorrhages from esophageal varices. A hemodynamic study]. Minerva Med. 1986 Mar 24;77(12):429-32. Italian. PubMed PMID: 2871526. 18: Lai C, Tallu B, Onnis E, Pirisi R, Cioglia G, Cherchi A. [Effects of acute administration of the levogyral beta-blocker levomoprolol on the exercise test in angina pectoris]. Cardiologia. 1984 Dec;29(12):605-14. Italian. PubMed PMID: 6152549. 19: Pecori-Giraldi J, Virno M, Ralli R, Planner-Terzaghi A. [Long-term treatment of wide-angle glaucoma with the beta blocker levomoprolol: therapeutic effectiveness without side effects]. Fortschr Ophthalmol. 1986;83(5):564-6. German. PubMed PMID: 2878862.