Synonym
Deacetyltrimepranol; Desacetylmetipranolol;
IUPAC/Chemical Name
1-(2,3,5-Trimethyl-4-hydroxyphenoxy)-3-isopropylamino-2-propanol hydrochloride
InChi Key
OJWSEZGHGQQXGC-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H25NO3.ClH/c1-9(2)16-7-13(17)8-19-14-6-10(3)15(18)12(5)11(14)4;/h6,9,13,16-18H,7-8H2,1-5H3;1H
SMILES Code
OC(CNC(C)C)COC1=CC(C)=C(O)C(C)=C1C.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
303.83
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Sharma SC, Evans MB, Evans SJ. The enantiomeric separation of metipranolol and desacetylmetipranolol on a cellulose tris-3,5-dimethylphenyl-carbamate chiral stationary phase. J Pharm Biomed Anal. 1995 Feb;13(2):129-37. PubMed PMID: 7766719.
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6: Tkaczyková M, Safarík L, Flegel M. [Determination of desacetylmetipranolol in blood using high performance liquid chromatography with electrochemical detection]. Cesk Farm. 1988 Sep;37(7):312-4. Czech. PubMed PMID: 2904305.
7: Peterková M, Matousová O, Rejholec V. [Densitometric determination of desacetylmetipranolol in blood plasma]. Cesk Farm. 1986 Dec;35(10):456-7. Czech. PubMed PMID: 2880671.
8: Garraffo R, Lapalus P. Determination of metipranolol and desacetylmetipranolol in aqueous humor of rabbit eye by gas chromatography with electron-capture detection. J Chromatogr. 1986 Nov 28;383(1):201-5. PubMed PMID: 2880856.
9: Vidal E, Guigues M, Balansard G, Elias R. Determination of ophthalmic therapeutic metipranolol and its degradation product by reversed-phase high-performance liquid chromatography. J Chromatogr. 1985 Nov 27;348(1):304-8. PubMed PMID: 2868022.
10: Endele R, Senn M, Abshagen U. Determination of deacetylmetipranolol in body fluids by gas chromatography--chemical-ionization mass spectrometry. J Chromatogr. 1982 Jan 8;227(1):187-92. PubMed PMID: 6120177.
