TDPAM02 | CAS#2231101-34-9

MedKoo Cat#: 555359 | Name: TDPAM02

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TDPAM02 is Potent Dimeric Positive Allosteric Modulator at the Ligand-Binding Domain of the GluA2 Receptor. TDPAM02 shows nanomolar potency at GluA2.

Chemical Structure

TDPAM02

CAS#2231101-34-9

Theoretical Analysis

MedKoo Cat#: 555359

Name: TDPAM02

CAS#: 2231101-34-9

Chemical Formula: C22H26N4O4S2

Exact Mass: 474.1395

Molecular Weight: 474.59

Elemental Analysis: C, 55.68; H, 5.52; N, 11.81; O, 13.48; S, 13.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

TDPAM02; TDPAM-02; TDPAM 02;

IUPAC/Chemical Name

6,6'-(ethane-1,2-diyl)bis(4-cyclopropyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide)

InChi Key

TVWVZMLPANTKEA-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H26N4O4S2/c27-31(28)21-9-3-15(11-19(21)25(13-23-31)17-5-6-17)1-2-16-4-10-22-20(12-16)26(18-7-8-18)14-24-32(22,29)30/h3-4,9-12,17-18,23-24H,1-2,5-8,13-14H2

SMILES Code

O=S(C1=C2C=C(CCC3=CC=C(S(NCN4C5CC5)(=O)=O)C4=C3)C=C1)(NCN2C6CC6)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 474.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor Saara Laulumaa, Kathrine Voigt Hansen, Magdalena Masternak, Thomas Drapier, Pierre Francotte, Bernard Pirotte, Karla Frydenvang, and Jette Sandholm Kastrup Publication Date (Web): November 4, 2018 (Letter) DOI: 10.1021/acsmedchemlett.8b00369