M 8506 | CAS#93245-29-5 | anti-malarial

MedKoo Cat#: 584658 | Name: M 8506

Description:

WARNING: This product is for research use only, not for human or veterinary use.

M 8506 can be used in the treatment of simian malaria and is is less toxic than primaquine in mice.

Chemical Structure

M 8506

CAS#93245-29-5

Theoretical Analysis

MedKoo Cat#: 584658

Name: M 8506

CAS#: 93245-29-5

Chemical Formula: C19H22F3N3O6

Exact Mass: 445.1461

Molecular Weight: 445.40

Elemental Analysis: C, 51.24; H, 4.98; F, 12.80; N, 9.43; O, 21.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

M 8506; M-8506; Trifluoroacetylprimaquine

IUPAC/Chemical Name

Ethanone, 1-(8-((4-amino-1-methylbutyl)amino)-6-methoxy-5-quinolinyl)-2,2,2-trifluoro-, ethanedioate (1:1)

InChi Key

WEFNQSNREJZFQJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H20F3N3O2.C2H2O4/c1-10(5-3-7-21)23-12-9-13(25-2)14(16(24)17(18,19)20)11-6-4-8-22-15(11)12;3-1(4)2(5)6/h4,6,8-10,23H,3,5,7,21H2,1-2H3;(H,3,4)(H,5,6)

SMILES Code

FC(F)(F)C(C1=C2C=CC=NC2=C(NC(C)CCCN)C=C1OC)=O.O=C(O)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 445.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ye XY, Shao BR. [Tissue schizontocidal action and acute toxicity of trifluoroacetyl primaquine]. Zhongguo Yao Li Xue Bao. 1990 Jul;11(4):359-62. Chinese. PubMed PMID: 2104491. 2: Ni YC, Xu YQ. [In vitro assay for detecting hemolytic toxicity of antimalarials incorporated with microsomal metabolic system]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1990;8(4):256-9. Chinese. PubMed PMID: 2099253. 3: Zheng XY, Chen C, Fang W. [Studies on the tissue schizonticide of malaria parasite: synthesis of 5-trieluoroacetyl-primaquine and its derivatives]. Yao Xue Xue Bao. 1992;27(6):423-7. Chinese. PubMed PMID: 1442069. 4: Shi X, Zhan C, Ha S, Yiao J. [Comparative study on hemolytic toxicity of trifluoroacetoprimaquine and primaquine in rabbits]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1994;12(3):218-20. Chinese. PubMed PMID: 7867160. 5: Ye X, Shao B, Chu Y. [Effect of trifluoroacetoprimaquine on erythrocytic schizonts of rodent malaria]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1994;12(3):223-4. Chinese. PubMed PMID: 7867162. 6: Shao BR, Ye XY. Tissue schizontocidal effect of trifluoroacetyl primaquine in Plasmodium yoelii infected mice and Plasmodium cynomolgi infected monkeys. Southeast Asian J Trop Med Public Health. 1991 Mar;22(1):81-3. PubMed PMID: 1948265.