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MedKoo Cat#: 584655 | Name: Emorfazone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Emorfazone has an anti-nociceptive effect.

Chemical Structure

Emorfazone
Emorfazone
CAS#38957-41-4

Theoretical Analysis

MedKoo Cat#: 584655

Name: Emorfazone

CAS#: 38957-41-4

Chemical Formula: C11H17N3O3

Exact Mass: 239.1270

Molecular Weight: 239.28

Elemental Analysis: C, 55.22; H, 7.16; N, 17.56; O, 20.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Emorfazone; M 73101; M73101
IUPAC/Chemical Name
3(2H)-Pyridazinone, 4-ethoxy-2-methyl-5-morpholino-
InChi Key
URJQOOISAKEBKW-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H17N3O3/c1-3-17-10-9(8-12-13(2)11(10)15)14-4-6-16-7-5-14/h8H,3-7H2,1-2H3
SMILES Code
O=C1C(OCC)=C(N2CCOCC2)C=NN1C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 239.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Piaz VD, Vergelli C, Giovannoni MP, Scheideler MA, Petrone G, Zaratin P. 4-Amino-3(2H)-pyridazinones bearing arylpiperazinylalkyl groups and related compounds: synthesis and antinociceptive activity. Farmaco. 2003 Nov;58(11):1063-71. PubMed PMID: 14572856. 2: Takaya M, Sato M. [Studies on pyridazinone derivatives. XVI. Analgesic-antiinflammatory activities of 3(2H)-pyridazinone derivatives]. Yakugaku Zasshi. 1994 Feb;114(2):94-110. Japanese. PubMed PMID: 8169774. 3: Khan AA, Malik S, Zuberi NI. Double blind study on emorfazone and ibuprofen in dental pain and inflammation. J Pak Med Assoc. 1992 Jan;42(1):17-8. PubMed PMID: 1545477. 4: Hiranuma T, Kato S, Hachisu M. Analgesic action of amfenac Na, a non-steroidal anti-inflammatory agent. J Pharmacobiodyn. 1988 Sep;11(9):612-9. PubMed PMID: 3265150. 5: Maki Y, Shimada K, Sako M, Kitade Y, Hirota K. Photochemical oxidation of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (Emorfazone) by pyrimido[5,4-g]pteridine 5-oxide. An attempt to apply a functional chemical model for biological oxidations to drug-metabolism studies. Chem Pharm Bull (Tokyo). 1988 May;36(5):1714-20. PubMed PMID: 3203412. 6: Yonehara N, Shibutani T, Inoki R. Contribution of substance P to heat-induced edema in rat paw. J Pharmacol Exp Ther. 1987 Sep;242(3):1071-6. PubMed PMID: 2443642. 7: Hatano M, Yamada T, Yoshida A, Miyata K, Okusawa S, Hoya I, Miura K, Ishihara M. [Studies on isolated rat hepatocytes (6)]. Josai Shika Daigaku Kiyo. 1984;13(1):156-64. Japanese. PubMed PMID: 6596968. 8: Hayashi T, Amino M, Ikoma Y. Changes of metabolism and substrate-binding spectrum of emorfazone between immature and mature guinea-pigs. Xenobiotica. 1983 Aug;13(8):461-6. PubMed PMID: 6649679. 9: Hayashi T. Metabolism of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (emorfazone). V. Effect of inducer pretreatment on oxygenation of the morpholino moiety in guinea pigs. Chem Pharm Bull (Tokyo). 1982 Oct;30(10):3748-56. PubMed PMID: 7160018. 10: Sato M. Effects of emorfazone on the nociceptive response induced by bradykinin in rats and dogs. Arch Int Pharmacodyn Ther. 1982 Jun;257(2):200-12. PubMed PMID: 6956248. 11: Sato M, Yamaguchi A. Studies on mechanisms of action of emorfazone. Effects on the release of bradykinin-like substance in thermic edema of rat paws. Arzneimittelforschung. 1982;32(4):379-82. PubMed PMID: 7201806. 12: Sato M, Kataoka M, Yamaguchi A. Pituitary-adrenocortical stimulation and anti-inflammatory actions of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101). J Pharmacobiodyn. 1981 Sep;4(9):649-55. PubMed PMID: 6278121. 13: Sato M, Ishizuka Y, Yamaguchi A. Pharmacological investigations of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M 73101), a new analgesic and anti-inflammatory drug. Arzneimittelforschung. 1981;31(10):1738-45. PubMed PMID: 6172134. 14: Hayashi T, Amino M, Yamaguchi A, Ohki M. [Metabolism of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101), a new anti-inflammatory agent. IV. Plasma concentration and absorption in various animals (author's transl)]. Yakugaku Zasshi. 1980 Jan;100(1):105-9. Japanese. PubMed PMID: 7373521. 15: Sato M. [Pharmacological studies of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101). (5) Action of M73101 on the central nervous system (author's transl)]. Nihon Yakurigaku Zasshi. 1979 Oct;75(7):695-706. Japanese. PubMed PMID: 575516. 16: Ishizuka Y, Sato M, Tanizawa H. [Pharmacological studies of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101). (4). Enzyme induction (author's transl)]. Nihon Yakurigaku Zasshi. 1979 Sep;75(6):633-43. Japanese. PubMed PMID: 120300. 17: Onodera C, Hayashi T, Makita I, Hashi T, Takeda K, Ozeki F, Shimazu H. [Chronic toxicity test of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101) in beagle dogs (author's transl)]. J Toxicol Sci. 1979 Aug;4(3):229-53. Japanese. PubMed PMID: 317111. 18: Sato M, Ishizuka Y, Tanizawa H, Fukuda T, Yuizono T. [Pharmacological studies of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101). (3). General pharmacological actions (author's transl)]. Nihon Yakurigaku Zasshi. 1979 Apr 20;75(3):291-307. Japanese. PubMed PMID: 317064. 19: Sato M, Ishizuka Y, Seki K, Tanizawa H, Fukuda T, Yuizono T. [Pharmacological studies of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101). (2). Anti-inflammatory activity (author's transl)]. Nihon Yakurigaku Zasshi. 1979 Mar;75(2):127-46. Japanese. PubMed PMID: 395049.