MedKoo Cat#: 573139 | Name: Amisometradine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amisometradine is a diuretic which may be used in the treatment of congestive heart failure.

Chemical Structure

Amisometradine
Amisometradine
CAS#550-28-7

Theoretical Analysis

MedKoo Cat#: 573139

Name: Amisometradine

CAS#: 550-28-7

Chemical Formula: C9H13N3O2

Exact Mass: 195.1008

Molecular Weight: 195.22

Elemental Analysis: C, 55.37; H, 6.71; N, 21.52; O, 16.39

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Synonym
Amisometradine, Aminoisometradin, Aminoisometradine, Rolicton
IUPAC/Chemical Name
6-Amino-3-methyl-1-(2-methylallyl)-2,4(1H,3H)-pyrimidinedione
InChi Key
FXNYSZHYMGWWEZ-UHFFFAOYSA-N
InChi Code
1S/C9H13N3O2/c1-6(2)5-12-7(10)4-8(13)11(3)9(12)14/h4H,1,5,10H2,2-3H3
SMILES Code
n1(c(n(c(=O)cc1N)C)=O)CC(C)=C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 195.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: VAN ARMAN CG, DETTELBACH HR, KAGAWA CM. A uracil diuretic: amisometradine (rolicton). Arch Int Pharmacodyn Ther. 1960 Jul 1;126:400-11. PubMed PMID: 13840955. 2: PLATTS MM. Amisometradine (rolicton) in the treatment of congestive heart failure. Br Heart J. 1959 Apr;21(2):249-54. PubMed PMID: 13651512; PubMed Central PMCID: PMC1017575. 3: BRUERA EF, BLANCO F, FERRARIO R, SCHILIAGGI E, GASPARY FV. [Comparative study of the diuretic effect of a mercurial, chlorothiazide & amisometradine]. Sem Med. 1959 Mar 26;114(13):404-7 passim. Spanish. PubMed PMID: 13659079. 4: SETTEL E. Observations on the prolonged administration of amisometradine. Am Pract Dig Treat. 1959 Mar;10(3):479-83. PubMed PMID: 13627415. 5: JOSE AD, WOOD P. Amisometradine, a new oral diuretic. Br Med J. 1958 Jan 4;1(5061):9-12. PubMed PMID: 13489295; PubMed Central PMCID: PMC2026628. 6: BELLE MS. Clinical experience with amisometradine (rolicton) on ambulatory patients. Am Heart J. 1958 Jan;55(1):114-9. PubMed PMID: 13520557.