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MedKoo Cat#: 564378 | Name: MMG-11
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MMG-11 is a potent and selective dual inhibitor of TLR2/1 and TLR2/6 signaling with low cytotoxicity.

Chemical Structure

MMG-11
CAS#313254-94-3

Theoretical Analysis

MedKoo Cat#: 564378

Name: MMG-11

CAS#: 313254-94-3

Chemical Formula: C15H14O7

Exact Mass: 306.0740

Molecular Weight: 306.27

Elemental Analysis: C, 58.83; H, 4.61; O, 36.57

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 weeks
50mg USD 1,150.00 2 weeks
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Related CAS #
No Data
Synonym
MMG11; MMG 11; MMG-11
IUPAC/Chemical Name
Ethyl 5-[2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl]furan-2-carboxylate
InChi Key
IIDUJWIVMGALOG-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H14O7/c1-2-21-15(20)12-6-3-8(22-12)7-11(17)9-4-5-10(16)14(19)13(9)18/h3-6,16,18-19H,2,7H2,1H3
SMILES Code
O=C(C1=CC=C(CC(C2=CC=C(O)C(O)=C2O)=O)O1)OCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7 µM for Pam3CSK4-induced hTLR2/1 and 5.7 µM for Pam2CSK4-induced hTLR2/6 responses.
In vitro activity:
In line with recent studies, MMG-11 abrogated pro-inflammatory cytokine secretion and NF-κB activation induced by different bacterial TLR2 agonists. MMG-11 preferentially inhibited TLR2/1 signaling in promoter cells stably expressing TLR2 heterodimers and mouse macrophages. Reference: Biochem Pharmacol. 2020 Jan;171:113687. https://pubmed.ncbi.nlm.nih.gov/31678495/
In vivo activity:
TBD
Solvent mg/mL mM comments
Solubility
DMSO 65.3 213.26
Ethanol 15.3 50.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 306.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Grabowski M, Murgueitio MS, Bermudez M, Wolber G, Weindl G. The novel small-molecule antagonist MMG-11 preferentially inhibits TLR2/1 signaling. Biochem Pharmacol. 2020 Jan;171:113687. doi: 10.1016/j.bcp.2019.113687. Epub 2019 Nov 1. PMID: 31678495. 2. Grabowski M, Murgueitio MS, Bermudez M, Rademann J, Wolber G, Weindl G. Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening. Biochem Pharmacol. 2018 Aug;154:148-160. doi: 10.1016/j.bcp.2018.04.018. Epub 2018 Apr 22. PMID: 29684378.
In vitro protocol:
1. Grabowski M, Murgueitio MS, Bermudez M, Wolber G, Weindl G. The novel small-molecule antagonist MMG-11 preferentially inhibits TLR2/1 signaling. Biochem Pharmacol. 2020 Jan;171:113687. doi: 10.1016/j.bcp.2019.113687. Epub 2019 Nov 1. PMID: 31678495. 2. Grabowski M, Murgueitio MS, Bermudez M, Rademann J, Wolber G, Weindl G. Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening. Biochem Pharmacol. 2018 Aug;154:148-160. doi: 10.1016/j.bcp.2018.04.018. Epub 2018 Apr 22. PMID: 29684378.
In vivo protocol:
TBD
1: Grabowski M, Murgueitio MS, Bermudez M, Rademann J, Wolber G, Weindl G. Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening. Biochem Pharmacol. 2018 Aug;154:148-160. doi: 10.1016/j.bcp.2018.04.018. Epub 2018 Apr 22. PubMed PMID: 29684378.