KIST301080 | ROS1 Inhibitor

MedKoo Cat#: 564354 | Name: KIST301080

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KIST301080 is a ROS1 kinase inhibitor.

Chemical Structure

KIST301080

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564354

Name: KIST301080

CAS#: NONE

Chemical Formula: C22H17N5O

Exact Mass: 367.1433

Molecular Weight: 367.41

Elemental Analysis: C, 71.92; H, 4.66; N, 19.06; O, 4.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

KIST-301080; KIST 301080; KIST301080

IUPAC/Chemical Name

2-(4-([2,3'-Bipyridin]-4-yl)-3-(3-hydroxy-5-methylphenyl)-1H-pyrazol-1-yl)acetonitrile

InChi Key

NUAUUAREUGURAU-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H17N5O/c1-15-9-18(11-19(28)10-15)22-20(14-27(26-22)8-5-23)16-4-7-25-21(12-16)17-3-2-6-24-13-17/h2-4,6-7,9-14,28H,8H2,1H3

SMILES Code

N#CCN1N=C(C2=CC(C)=CC(O)=C2)C(C3=CC(C4=CC=CN=C4)=NC=C3)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 367.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Abdelazem AZ, Lee SH. Synthesis and biological evaluation of new pyrimidine-4-yl-ethanol derivatives as ROS1 kinase inhibitors. J Enzyme Inhib Med Chem. 2015 Apr;30(2):290-8. doi: 10.3109/14756366.2014.920838. Epub 2014 Jun 18. PubMed PMID: 24939104.