UNC4203 is a potent and selective MERTK Inhibitor. UNC4203 showed IC50 MerTK=2.4 nM (Ki=0.42 nM); IC50 Axl = 80 nM (Ki=40.22 nM); IC50 Tyro3 = 9.1 nM (Ki=3.87 nM). IC50 FLT3 = 39 nM *Ki=16.14 nM). T1/2 = 3.0 h; %F=15. UNC4203 may be a potential candidate for cancer treatment.
MedKoo Cat#: 407943
Name: UNC4203
CAS#: 1818234-19-3
Chemical Formula: C30H44N6O
Exact Mass: 504.3577
Molecular Weight: 504.72
Elemental Analysis: C, 71.39; H, 8.79; N, 16.65; O, 3.17
The following data is based on the product molecular weight 504.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
