TH 1217, also known as ZINC1775962367, is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19.
MedKoo Cat#: 584646
Name: TH-1217
CAS#: 1862212-48-3
Chemical Formula: C20H17BCl2N4O6
Exact Mass: 490.0618
Molecular Weight: 491.09
Elemental Analysis: C, 48.92; H, 3.49; B, 2.20; Cl, 14.44; N, 11.41; O, 19.55
The following data is based on the product molecular weight 491.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
