Bromethalin | CAS#63333-35-7

MedKoo Cat#: 341619 | Name: Bromethalin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bromethalin works by uncoupling mitochondrial oxidative phosphorylation.

Chemical Structure

Bromethalin

CAS#63333-35-7

Theoretical Analysis

MedKoo Cat#: 341619

Name: Bromethalin

CAS#: 63333-35-7

Chemical Formula: C14H7Br3F3N3O4

Exact Mass: 574.7939

Molecular Weight: 577.93

Elemental Analysis: C, 29.10; H, 1.22; Br, 41.48; F, 9.86; N, 7.27; O, 11.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Bromethalin; EL 614; EL-614; EL614.

IUPAC/Chemical Name

N-Methyl-2,4-dinitro-N-(2,4,6-tribromophenyl)-6-(trifluoromethyl)benzenamine

InChi Key

USMZPYXTVKAYST-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H7Br3F3N3O4/c1-21(13-9(16)2-6(15)3-10(13)17)12-8(14(18,19)20)4-7(22(24)25)5-11(12)23(26)27/h2-5H,1H3

SMILES Code

FC(C1=C(N(C)C2=C(Br)C=C(Br)C=C2Br)C([N+]([O-])=O)=CC([N+]([O-])=O)=C1)(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 577.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lehner A, Bokhart M, Johnson M, Buchweitz J. Characterization of Bromethalin and its Degradation Products in Veterinary Toxicology Samples by GC-MS-MS. J Anal Toxicol. 2018 Oct 11. doi: 10.1093/jat/bky072. [Epub ahead of print] PubMed PMID: 30307505. 2: DeClementi C, Sobczak BR. Common Rodenticide Toxicoses in Small Animals. Vet Clin North Am Small Anim Pract. 2018 Nov;48(6):1027-1038. doi: 10.1016/j.cvsm.2018.06.006. Epub 2018 Aug 31. Review. PubMed PMID: 30173927. 3: Walton KL, Otto CM. Retrospective evaluation of feline rodenticide exposure and gastrointestinal decontamination: 146 cases (2000-2010). J Vet Emerg Crit Care (San Antonio). 2018 Sep;28(5):457-463. doi: 10.1111/vec.12748. Epub 2018 Aug 21. PubMed PMID: 30129699. 4: Becker MD, Young BC. Treatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011-2014). Vet Med (Auckl). 2017 Oct 30;8:77-85. doi: 10.2147/VMRR.S129576. eCollection 2017. PubMed PMID: 30050859; PubMed Central PMCID: PMC6042488. 5: Romano MC, Loynachan AT, Bolin DC, Bryant UK, Kennedy L, Filigenzi MS, Puschner B, Poppenga RH, Gaskill CL. Fatal bromethalin intoxication in 3 cats and 2 dogs with minimal or no histologic central nervous system spongiform change. J Vet Diagn Invest. 2018 Jul;30(4):642-645. doi: 10.1177/1040638718775463. Epub 2018 May 2. PubMed PMID: 29717638. 6: Heggem-Perry B, McMichael M, O'Brien M, Moran C. Intravenous Lipid Emulsion Therapy for Bromethalin Toxicity in a Dog. J Am Anim Hosp Assoc. 2016 Jul-Aug;52(4):265-8. doi: 10.5326/JAAHA-MS-6396. Epub 2016 Jun 3. PubMed PMID: 27259025. 7: Huntington S, Fenik Y, Vohra R, Geller RJ. Human bromethalin exposures reported to a U.S. Statewide Poison Control System. Clin Toxicol (Phila). 2016 Mar;54(3):277-81. doi: 10.3109/15563650.2016.1139713. Epub 2016 Feb 9. PubMed PMID: 26860212. 8: Shekhawat P, Rajagopalan L, Thompson V. Bright Green Stool in a Toddler's Diaper. Bromethalin rodenticide ingestion. Ann Emerg Med. 2015 Nov;66(5):464, 495. doi: 10.1016/j.annemergmed.2015.01.023. PubMed PMID: 26497431. 9: Bates MC, Roady P, Lehner AF, Buchweitz JP, Heggem-Perry B, Lezmi S. Atypical bromethalin intoxication in a dog: pathologic features and identification of an isomeric breakdown product. BMC Vet Res. 2015 Sep 28;11:244. doi: 10.1186/s12917-015-0554-y. PubMed PMID: 26419228; PubMed Central PMCID: PMC4584469. 10: Filigenzi MS, Bautista AC, Aston LS, Poppenga RH. Method for the detection of desmethylbromethalin in animal tissue samples for the determination of bromethalin exposure. J Agric Food Chem. 2015 Jun 3;63(21):5146-51. doi: 10.1021/jf5052706. Epub 2015 Mar 3. PubMed PMID: 25688571. 11: Cima G. Help line getting more calls about bromethalin. J Am Vet Med Assoc. 2014 Jul 15;245(2):169. PubMed PMID: 25115021. 12: Pritt ML, Hall DG, Jordan WH, Ballard DW, Wang KK, Müller UR, Watson DE. Initial biological qualification of SBDP-145 as a biomarker of compound-induced neurodegeneration in the rat. Toxicol Sci. 2014 Oct;141(2):398-408. doi: 10.1093/toxsci/kfu136. Epub 2014 Jul 11. PubMed PMID: 25015659; PubMed Central PMCID: PMC4833023. 13: Istvan SA, Marks SL, Murphy LA, Dorman DC. Evaluation of a point-of-care anticoagulant rodenticide test for dogs. J Vet Emerg Crit Care (San Antonio). 2014 Mar-Apr;24(2):168-73. doi: 10.1111/vec.12140. Epub 2014 Jan 6. PubMed PMID: 24393382. 14: Rubinstein I, Weinberg G. Antidote for bromethalin poisoning. Can Vet J. 2014 Jan;55(1):1185. Erratum in: Can Vet J. 2014 Feb;55(2):106. PubMed PMID: 24381335; PubMed Central PMCID: PMC3866846. 15: Bautista AC, Woods LW, Filigenzi MS, Puschner B. Bromethalin poisoning in a raccoon (Procyon lotor): diagnostic considerations and relevance to nontarget wildlife. J Vet Diagn Invest. 2014 Jan;26(1):154-7. doi: 10.1177/1040638713510296. Epub 2013 Dec 9. PubMed PMID: 24323056. 16: Coppock R. Advisory: Bromethalin rodenticide - No known antidote. Can Vet J. 2013 Jun;54(6):557-8. PubMed PMID: 24155445; PubMed Central PMCID: PMC3659449. 17: Peterson ME. Bromethalin. Top Companion Anim Med. 2013 Feb;28(1):21-3. doi: 10.1053/j.tcam.2013.03.005. Review. PubMed PMID: 23796484. 18: DeClementi C, Sobczak BR. Common rodenticide toxicoses in small animals. Vet Clin North Am Small Anim Pract. 2012 Mar;42(2):349-60, viii. doi: 10.1016/j.cvsm.2011.12.008. Epub 2012 Jan 9. Review. PubMed PMID: 22381184. 19: Zawadzki M, Magdalan J, Niedźwiedź A. [Poisonings with anticoagulant rodenticides]. Arch Med Sadowej Kryminol. 2007 Oct-Dec;57(4):427-9. Review. Polish. PubMed PMID: 18432144. 20: Pasquale-Styles MA, Sochaski MA, Dorman DC, Krell WS, Shah AK, Schmidt CJ. Fatal bromethalin poisoning. J Forensic Sci. 2006 Sep;51(5):1154-7. PubMed PMID: 17018099.