BAY-826 | CAS# 1448316-08-2 | TIE-2-Inhibitor

MedKoo Cat#: 564292 | Name: BAY-826

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BAY-826 is a highly potent, orally available TIE-2-inhibitor which improves tumor control in syngeneic mouse glioma models.

Chemical Structure

BAY-826

CAS#1448316-08-2

Theoretical Analysis

MedKoo Cat#: 564292

Name: BAY-826

CAS#: 1448316-08-2

Chemical Formula: C26H19F5N6OS

Exact Mass: 558.1261

Molecular Weight: 558.53

Elemental Analysis: C, 55.91; H, 3.43; F, 17.01; N, 15.05; O, 2.86; S, 5.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

BAY826; BAY 826; BAY-826

IUPAC/Chemical Name

3-Cyano-N-(2,4-dimethyl-5-(6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl)phenyl)-5-(pentafluoro-l6-sulfaneyl)benzamide

InChi Key

MPASHPJAIUOWCK-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H19F5N6OS/c1-16-8-17(2)24(36-6-7-37-25(36)13-23(35-37)19-4-3-5-33-15-19)12-22(16)34-26(38)20-9-18(14-32)10-21(11-20)39(27,28,29,30)31/h3-13,15H,1-2H3,(H,34,38)

SMILES Code

O=C(NC1=CC(N2C=CN3N=C(C4=CC=CN=C4)C=C32)=C(C)C=C1C)C5=CC(S(F)(F)(F)(F)F)=CC(C#N)=C5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 558.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Schneider H, Szabo E, Machado RA, Broggini-Tenzer A, Walter A, Lobell M, Heldmann D, Süssmeier F, Grünewald S, Weller M. Novel TIE-2 inhibitor BAY-826 displays in vivo efficacy in experimental syngeneic murine glioma models. J Neurochem. 2017 Jan;140(1):170-182. doi: 10.1111/jnc.13877. Epub 2016 Dec 12. PubMed PMID: 27787897.