Tectoridin | CAS#611-40-5 | Highly active isoflavone

MedKoo Cat#: 584641 | Name: Tectoridin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tectoridin is a glycosylated tectorigenin which has antitumor activity against prostate and colon cancer. Tectoridin (Tec) is a highly active isoflavone with anti-inflammatory pharmacological activity.

Chemical Structure

Tectoridin

CAS#611-40-5

Theoretical Analysis

MedKoo Cat#: 584641

Name: Tectoridin

CAS#: 611-40-5

Chemical Formula: C22H22O11

Exact Mass: 462.1162

Molecular Weight: 462.41

Elemental Analysis: C, 57.14; H, 4.80; O, 38.06

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 350.00
50mg	USD 800.00

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Related CAS #

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Synonym

Tectoridin; Shekanin

IUPAC/Chemical Name

7-(beta-D-Glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one

InChi Key

CNOURESJATUGPN-UDEBZQQRSA-N

InChi Code

InChI=1S/C22H22O11/c1-30-21-13(32-22-20(29)19(28)17(26)14(7-23)33-22)6-12-15(18(21)27)16(25)11(8-31-12)9-2-4-10(24)5-3-9/h2-6,8,14,17,19-20,22-24,26-29H,7H2,1H3/t14-,17-,19+,20-,22-/m1/s1

SMILES Code

O=C1C(C2=CC=C(O)C=C2)=COC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=C(OC)C(O)=C13

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 462.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Alruwad MI, Salah El Dine R, Gendy AM, Saleh AM, Khalaf MA, El Hefnawy HM, Sabry MM. Insights into Clematis cirrhosa L. Ethanol Extract: Cytotoxic Effects, LC-ESI-QTOF-MS/MS Chemical Profiling, Molecular Docking, and Acute Toxicity Study. Pharmaceuticals (Basel). 2024 Oct 9;17(10):1347. doi: 10.3390/ph17101347. PMID: 39458988; PMCID: PMC11510288. 2: Hu JD, Dong LH, Zhu WF, Wang B, Chen YM, Wang XY, Zhu YY, Ge F. [Genetic diversity of SP1 population of space mutagenized Pueraria montana]. Zhongguo Zhong Yao Za Zhi. 2024 Jul;49(14):3736-3748. Chinese. doi: 10.19540/j.cnki.cjcmm.20240415.102. PMID: 39099348. 3: Liang H, Li XY, Zhang XW, Bao YW, Ding ML, Yuan QH, He CS, Zeng N. [Mechanism of Ganke Granules intervening acute lung injury based on network pharmacology and experimental verification]. Zhongguo Zhong Yao Za Zhi. 2024 Apr;49(8):2197-2209. Chinese. doi: 10.19540/j.cnki.cjcmm.20240115.706. PMID: 38812235. 4: Wang Z, Jiang Y, Li Z, Weng L, Xiao C. Herbal textual research of Belamcanda chinensis (L.) redouté and screening of quality-markers based on 'pharmacodynamics-substance'. J Ethnopharmacol. 2024 Oct 5;332:118324. doi: 10.1016/j.jep.2024.118324. Epub 2024 May 14. PMID: 38754643. 5: Cao W, Guo X, Li X, Chen D. Commentary on: Activation of Nrf2 signalling pathway by tectoridin protects against ferroptosis in particulate matter-induced lung injury. Br J Pharmacol. 2024 Aug;181(15):2697-2698. doi: 10.1111/bph.16418. Epub 2024 May 6. PMID: 38710916. 6: Zhang Q, Wang L, Yu L, Yu Q, Xue L, Shen Z. Tectoridin inhibits the growth of bladder cancer by regulating PI3K/MAPK pathway through RAB27B. Mol Carcinog. 2024 Jun;63(6):1106-1116. doi: 10.1002/mc.23712. Epub 2024 Mar 5. PMID: 38441297. 7: Zhang K, Lv J, Shen J, Zhang N, Gao X, Li C, Sun J, Wang Y. Exploring Asthma Mechanism of Belamcanda Chinensis by "Dose-effect Weighted Coefficient" Network Pharmacology and Experiment Validation. Comb Chem High Throughput Screen. 2023 Nov 22. doi: 10.2174/0113862073254607231107074015. Epub ahead of print. PMID: 38155401. 8: Zhou L, Yu J, Wang S, Ma Y, Liu X, Zhang X, Luo Y, Wen S, Li L, Li W, Niu X. Tectoridin alleviates caerulein-induced severe acute pancreatitis by targeting ERK2 to promote macrophage M2 polarization. Arch Biochem Biophys. 2024 Feb;752:109873. doi: 10.1016/j.abb.2023.109873. Epub 2023 Dec 21. PMID: 38141907. 9: Zhang M, Wang B, Li XT, Yin Q, Liang G, Li SC. Impact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats. Xenobiotica. 2023 May;53(5):429-437. doi: 10.1080/00498254.2023.2261040. Epub 2023 Oct 5. PMID: 37781957. 10: Niu K, Wang H, Kim SK, Wassie T, Wu X. Stepwise co-fermented traditional Chinese medicine byproducts improve antioxidant and anti-inflammatory effects in a piglet model. J Sci Food Agric. 2024 Jan 30;104(2):1166-1177. doi: 10.1002/jsfa.13002. Epub 2023 Oct 5. PMID: 37740928. 11: Liu Q, Li J, Gu M, Kong W, Lin Z, Mao J, Zhang M, Jiang L, Liu C, Wang Y, Liu J. High-Throughput Phytochemical Unscrambling of Flowers Originating from Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) P. K. Hsiao and Astragalus membranaceus (Fisch.) Bug. by Applying the Intagretive Plant Metabolomics Method Using UHPLC-Q-TOF-MS/MS. Molecules. 2023 Aug 18;28(16):6115. doi: 10.3390/molecules28166115. PMID: 37630367; PMCID: PMC10458299. 12: Cheng W, Fang X, Guan Z, Yao Y, Xu Z, Bi Y, Ren K, Li J, Chen F, Chen X, Ma W, Chu Z, Deng Z, Zhang Z, Lu L. Functional characterization and structural basis of a reversible glycosyltransferase involves in plant chemical defence. Plant Biotechnol J. 2023 Dec;21(12):2611-2624. doi: 10.1111/pbi.14157. Epub 2023 Aug 15. PMID: 37581303; PMCID: PMC10651139. 13: Wang J, Tang Y, Lv X, Zhang J, Ma B, Wen X, Bao Y, Wang G. Corrigendum: "Tectoridin inhibits osteoclastogenesis and bone loss in a murine model of ovariectomy-induced osteoporosis" [Exp. Gerontol. 140: 2020; 111057. DOI:10.1016/j.exger.2020.111057]. Exp Gerontol. 2023 Sep;180:112251. doi: 10.1016/j.exger.2023.112251. Epub 2023 Jul 22. Erratum for: Exp Gerontol. 2020 Oct 15;140:111057. doi: 10.1016/j.exger.2020.111057. PMID: 37487835. 14: Li QH, Shan XX, Ye WD, Yin XY, Yuan YM, Fang XM. [Research progress of Shegan Mahuang Decoction and predictive analysis on its Q-markers]. Zhongguo Zhong Yao Za Zhi. 2023 Apr;48(8):2068-2076. Chinese. doi: 10.19540/j.cnki.cjcmm.20230302.201. PMID: 37282895. 15: Zhang H, Wei Z, Tong Y, Song X, Li S, Sun Y, Liu C, Han F, Yu J. Spectrum- effect relationship study to reveal the pharmacodynamic substances in Flos Puerariae-Semen Hoveniae medicine pair for the treatment of alcohol-induced liver damage. J Ethnopharmacol. 2023 Oct 5;314:116628. doi: 10.1016/j.jep.2023.116628. Epub 2023 May 15. PMID: 37196817. 16: Liu S, Qin HH, Ji XR, Gan JW, Sun MJ, Tao J, Tao ZQ, Zhao GN, Ma BX. Virtual Screening of Nrf2 Dietary-Derived Agonists and Safety by a New Deep-Learning Model and Verified In Vitro and In Vivo. J Agric Food Chem. 2023 May 31;71(21):8038-8049. doi: 10.1021/acs.jafc.3c00867. Epub 2023 May 17. PMID: 37196215. 17: Wang M, Zhao F, Li Z, Li X, Dong L. Tectoridin and PLK1 inhibitor synergistically promote the apoptosis of lung adenocarcinoma cells: Bioinformatic analysis of TCGA and TCMSP. Naunyn Schmiedebergs Arch Pharmacol. 2023 Oct;396(10):2417-2426. doi: 10.1007/s00210-023-02460-2. Epub 2023 Apr 4. PMID: 37014402. 18: Dong T, Fan X, Zheng N, Yan K, Hou T, Peng L, Ci X. Activation of Nrf2 signalling pathway by tectoridin protects against ferroptosis in particulate matter-induced lung injury. Br J Pharmacol. 2023 Oct;180(19):2532-2549. doi: 10.1111/bph.16085. Epub 2023 Jun 25. PMID: 37005797. 19: Chen C, Li X, Kano Y, Yuan D, Qu J. Oriental traditional herbal Medicine-- Puerariae Flos: A systematic review. J Ethnopharmacol. 2023 Apr 24;306:116089. doi: 10.1016/j.jep.2022.116089. Epub 2023 Jan 5. PMID: 36621660. 20: Chen M, Lu Y, Zhou M, Wang W, Zheng M, Liu C. The protection impact of tectoridin on PC12 cell preventing OGD/R-caused damage through PI3K/AKT signaling channel. Eur J Pharmacol. 2023 Feb 15;941:175491. doi: 10.1016/j.ejphar.2023.175491. Epub 2023 Jan 5. PMID: 36610685.