MedKoo Cat#: 584635 | Name: Nexinhib20
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nexinhib20 is a Rab27 inhibitor that inhibits neutrophil exocytosis and is active in vivo.

Chemical Structure

Nexinhib20
CAS#331949-35-0

Theoretical Analysis

MedKoo Cat#: 584635

Name: Nexinhib20

CAS#: 331949-35-0

Chemical Formula: C15H16N4O3

Exact Mass: 300.1222

Molecular Weight: 300.32

Elemental Analysis: C, 59.99; H, 5.37; N, 18.66; O, 15.98

Price and Availability

Size Price Availability Quantity
5mg USD 250.00
25mg USD 560.00
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Nexinhib20
IUPAC/Chemical Name
4,4-Dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one
InChi Key
VKSOIYNNOFGGES-JYRVWZFOSA-N
InChi Code
InChI=1S/C15H16N4O3/c1-15(2,3)14(20)13(18-10-16-9-17-18)8-11-5-4-6-12(7-11)19(21)22/h4-10H,1-3H3/b13-8-
SMILES Code
CC(C)(C)C(/C(N1N=CN=C1)=C/C2=CC=CC([N+]([O-])=O)=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 300.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Johnson et al (2016) Identification of neutrophil exocytosis inhibitors (Nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: druggability of the small GTPase Rab27a. J.Biol.Chem. 291 25965 PMID: 27702998