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MedKoo Cat#: 564271 | Name: ADP-2341

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ADP-2341 is a soluble analog of FiVe1. ADP-2341 displayed enhanced solubility with respect to FiVe1 and retained potent and selective cellular activity in proliferation assay.

Chemical Structure

ADP-2341
CAS#2149619-47-4

Theoretical Analysis

MedKoo Cat#: 564271

Name: ADP-2341

CAS#: 2149619-47-4

Chemical Formula: C24H29Cl2N5O3

Exact Mass: 505.1647

Molecular Weight: 506.43

Elemental Analysis: C, 56.92; H, 5.77; Cl, 14.00; N, 13.83; O, 9.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ADP2341; ADP 2341; ADP-2341
IUPAC/Chemical Name
2-(2-(2-(3-chloro-5-(4-(8-chlorocinnolin-4-yl)piperazin-1-yl)phenoxy)ethoxy)ethoxy)ethan-1-amine
InChi Key
MSZAROLOQGWZRX-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H29Cl2N5O3/c25-18-14-19(16-20(15-18)34-13-12-33-11-10-32-9-4-27)30-5-7-31(8-6-30)23-17-28-29-24-21(23)2-1-3-22(24)26/h1-3,14-17H,4-13,27H2
SMILES Code
NCCOCCOCCOC1=CC(N2CCN(C3=C4C=CC=C(Cl)C4=NN=C3)CC2)=CC(Cl)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Expression of the transcription factor FOXC2 is induced and necessary for successful epithelial-​mesenchymal transition, a developmental program that when activated in cancer endows cells with metastatic potential and the properties of stem cells. As such, identifying agents that inhibit the growth of FOXC2-​transformed cells represents an attractive approach to inhibit chemotherapy resistance and metastatic dissemination.

Preparing Stock Solutions

The following data is based on the product molecular weight 506.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Bollong MJ, Pietilä M, Pearson AD, et al. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proc Natl Acad Sci U S A. 2017;114(46):E9903-E9912. doi:10.1073/pnas.1716009114