IVDE77 | Ang IV-analogue

MedKoo Cat#: 564225 | Name: IVDE77

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IVDE77 is the first Ang IV-analogue with the ability to abolish IRAP-availability completely at the cell surface in vitro.

Chemical Structure

IVDE77

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564225

Name: IVDE77

CAS#: NONE

Chemical Formula: C47H61N7O8

Exact Mass: 851.4582

Molecular Weight: 852.05

Elemental Analysis: C, 66.25; H, 7.22; N, 11.51; O, 15.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

IVDE-77; IVDE 77; IVDE77

IUPAC/Chemical Name

((S)-2-((S)-4-((2S,3S)-2-((S)-2-((R)-2-(aminomethyl)-3-methylbutanamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl)pentanoyl)-L-phenylalanine

InChi Key

AAPRWZFIOAUINZ-AGAFZLDISA-N

InChi Code

InChI=1S/C47H61N7O8/c1-6-13-40(44(58)52-38(47(61)62)23-29-14-9-8-10-15-29)54-26-39-33(32-16-11-12-17-35(32)49-39)24-37(46(54)60)51-45(59)41(28(5)7-2)53-43(57)36(22-30-18-20-31(55)21-19-30)50-42(56)34(25-48)27(3)4/h8-12,14-21,27-28,34,36-38,40-41,49,55H,6-7,13,22-26,48H2,1-5H3,(H,50,56)(H,51,59)(H,52,58)(H,53,57)(H,61,62)/t28-,34-,36-,37-,38-,40-,41-/m0/s1

SMILES Code

NC[C@@H](C(C)C)C(N[C@H](C(N[C@@H]([C@H](CC)C)C(N[C@@H](CC1=C(NC2=C1C=CC=C2)C3)C(N3[C@@H](CCC)C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 852.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nikolaou A, Van den Eynde I, Tourwé D, Vauquelin G, Tóth G, Mallareddy JR, Poglitsch M, Van Ginderachter JA, Vanderheyden PM. [3H]IVDE77, a novel radioligand with high affinity and selectivity for the insulin-regulated aminopeptidase. Eur J Pharmacol. 2013 Feb 28;702(1-3):93-102. doi: 10.1016/j.ejphar.2013.01.026. Epub 2013 Jan 31. PubMed PMID: 23376157. 2: Nikolaou A, Stijlemans B, Laoui D, Schouppe E, Tran HT, Tourwé D, Chai SY, Vanderheyden PM, Van Ginderachter JA. Presence and regulation of insulin-regulated aminopeptidase in mouse macrophages. J Renin Angiotensin Aldosterone Syst. 2014 Dec;15(4):466-79. doi: 10.1177/1470320313507621. Epub 2014 Feb 14. PubMed PMID: 24532823.