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MedKoo Cat#: 527984 | Name: Luminamicin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Luminamicin is active against anaerobic bacteria, especially Clostridium sp.; isolated from actinomycete strain OMR-59.

Chemical Structure

Luminamicin
Luminamicin
CAS#99820-21-0

Theoretical Analysis

MedKoo Cat#: 527984

Name: Luminamicin

CAS#: 99820-21-0

Chemical Formula: C32H43O12

Exact Mass: 619.2755

Molecular Weight: 619.68

Elemental Analysis: C, 62.02; H, 6.99; O, 30.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Luminamicin
IUPAC/Chemical Name
1,24-Methano-1H,9H,15H-furo(3',4':10,11)(1,7)dioxacyclotetradecino(4,3-e)pyrano(2,3-i)(4)benzoxecin-6,13,15,18(3ah)-tetrone, 4,5,7a,8,16,17,20,20a,24,25,26,26a-dodecahydro-8,26-dihydroxy-22,25-dimethyl-5-methoxy-
InChi Key
GMJLNBXTJZQZBR-QBSSALJOSA-N
InChi Code
InChI=1S/C32H43O12/c1-17-6-7-19-14-44(38)15-20(19)11-27(35)42-28(36)13-25-29-18(2)31(37)32-21(5-4-10-43(32)16-26(29)41-17)30(39-3)24(34)12-22(32)23(33)8-9-40-25/h6,18,21-23,26,30-31,33,37H,4-5,7-16H2,1-3H3/b17-6+,29-25+
SMILES Code
O=C(C(OC)C1CCCO2CC/3O/C(C)=C/CC4=C(CO(C4)=O)CC5=O)CC6C12C(O)C(C)C3=C(CC(O5)=O)/OCCC6O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 619.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ando H, Kimishima A, Ohara M, Hirose T, Matsumaru T, Takada H, Morodome K, Miyamoto T, Sugawara A, Ōmura S, Sunazuka T. Toward the total synthesis of luminamicin; an anaerobic antibiotic: construction of highly functionalized cis-decalin containing a bridged ether moiety. J Antibiot (Tokyo). 2018 Feb;71(2):268-272. doi: 10.1038/ja.2017.77. Epub 2017 Jul 5. PubMed PMID: 28676718. 2: Gouda H, Sunazuka T, Ui H, Handa M, Sakoh Y, Iwai Y, Hirono S, Omura S. Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18286-91. Epub 2005 Dec 12. PubMed PMID: 16344486; PubMed Central PMCID: PMC1317948. 3: Rasmussen RR, Scherr MH, Whittern DN, Buko AM, McAlpine JB. Coloradocin, an antibiotic from a new Actinoplanes. II. Identity with luminamicin and elucidation of structure. J Antibiot (Tokyo). 1987 Oct;40(10):1383-93. PubMed PMID: 3680004. 4: Jackson M, Karwowski JP, Theriault RJ, Fernandes PB, Semon RC, Kohl WL. Coloradocin, an antibiotic from a new Actinoplanes. I. Taxonomy, fermentation and biological properties. J Antibiot (Tokyo). 1987 Oct;40(10):1375-82. PubMed PMID: 3680003. 5: Taga S, Takahashi Y, Iwai Y, Omura S. Taxonomic study of luminamicin-producing actinomycete strain OMR-59. Kitasato Arch Exp Med. 1987 Jun;60(1-2):15-24. PubMed PMID: 3669500. 6: Tomoda H, Iwata R, Takahashi Y, Iwai Y, Oiwa R, Omura S. Lustromycin, a new antibiotic produced by Streptomyces sp. J Antibiot (Tokyo). 1986 Sep;39(9):1205-10. PubMed PMID: 3781918. 7: Omura S, Iwata R, Iwai Y, Taga S, Tanaka Y, Tomoda H. Luminamicin, a new antibiotic. Production, isolation and physico-chemical and biological properties. J Antibiot (Tokyo). 1985 Oct;38(10):1322-6. PubMed PMID: 3840790.