MedKoo Cat#: 527983 | Name: Diacetyl boldine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diacetyl boldine is a natural product from the bark of the Chilean Boldo tree. Diacetyl boldine works as a skin lightening agent in skin care products. Diacetyl boldine is widely used in cosmetic products such as facial moisturizer/lotion, anti-aging treatment, cleanser, sunscreen, skin fader/lightener, concealer, toner and acne treatme.

Chemical Structure

Diacetyl boldine
CAS#72584-75-9

Theoretical Analysis

MedKoo Cat#: 527983

Name: Diacetyl boldine

CAS#: 72584-75-9

Chemical Formula: C23H25NO6

Exact Mass: 411.1682

Molecular Weight: 411.45

Elemental Analysis: C, 67.14; H, 6.12; N, 3.40; O, 23.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Diacetyl boldine; Diacetylboldine; Lumiskin; Lumisphere;
IUPAC/Chemical Name
4H-Dibenzo(de,g)quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, 2,9-diacetate, (6aS)-
InChi Key
XMEDXTRRSJHOLZ-KRWDZBQOSA-N
InChi Code
InChI=1S/C23H25NO6/c1-12(25)29-19-10-15-8-17-21-14(6-7-24(17)3)9-20(30-13(2)26)23(28-5)22(21)16(15)11-18(19)27-4/h9-11,17H,6-8H2,1-5H3/t17-/m0/s1
SMILES Code
CN1CCC2=CC(OC(C)=O)=C(OC)C3=C2[C@]1([H])CC4=CC(OC(C)=O)=C(OC)C=C34
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 411.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pratchyapurit WO. Combined use of two formulations containing diacetyl boldine, TGF-β1 biomimetic oligopeptide-68 with other hypopigmenting/exfoliating agents and sunscreen provides effective and convenient treatment for facial melasma. Either is equal to or is better than 4% hydroquinone on normal skin. J Cosmet Dermatol. 2016 Jun;15(2):131-44. doi: 10.1111/jocd.12201. Epub 2016 Feb 2. PubMed PMID: 26833454. 2: Thomet FA, Pinyol P, Villena J, Espinoza LJ, Reveco PG. Cytotoxic thiocarbamate derivatives of boldine. Nat Prod Commun. 2010 Oct;5(10):1587-90. PubMed PMID: 21121254. 3: Chi TC, Lee SS, Su MJ. Antihyperglycemic effect of aporphines and their derivatives in normal and diabetic rats. Planta Med. 2006 Oct;72(13):1175-80. Epub 2006 Aug 21. PubMed PMID: 16924583.