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MedKoo Cat#: 527977 | Name: Lumicolchicine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lumicolchicine is a bioactive chemical.

Chemical Structure

Lumicolchicine
Lumicolchicine
CAS#6901-13-9

Theoretical Analysis

MedKoo Cat#: 527977

Name: Lumicolchicine

CAS#: 6901-13-9

Chemical Formula: C22H25NO6

Exact Mass: 399.1682

Molecular Weight: 399.44

Elemental Analysis: C, 66.15; H, 6.31; N, 3.51; O, 24.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Lumicolchicine
IUPAC/Chemical Name
(7S-(7alpha,7bbeta,10abeta))-N-(5,6,7,7b,8,10a-Hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo(a)cyclopenta(3,4)cyclobuta(1,2-c)cyclohepten-7-yl)acetamide
InChi Key
VKPVZFOUXUQJMW-FHSNZYRGSA-N
InChi Code
InChI=1S/C22H25NO6/c1-10(24)23-13-7-6-11-8-15(27-3)21(28-4)22(29-5)16(11)17-12-9-14(26-2)20(25)18(12)19(13)17/h8-9,12-13,18H,6-7H2,1-5H3,(H,23,24)/t12-,13+,18-/m1/s1
SMILES Code
CC(N[C@@H]1C([C@@]2([H])[C@]3([H])C=C(OC)C2=O)=C3C4=C(OC)C(OC)=C(OC)C=C4CC1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 399.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Role of microtubules in estradiol-17beta-D-glucuronide-induced alteration of canalicular Mrp2 localization and activity. Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G327-36. Epub 2004 Sep 16. PubMed PMID: 15374814. 12: Riley NE, Bardag-Gorce F, Montgomery RO, Li J, Lungo W, Lue YH, French SW. Microtubules are required for cytokeratin aggresome (Mallory body) formation in hepatocytes: an in vitro study. Exp Mol Pathol. 2003 Apr;74(2):173-9. PubMed PMID: 12710949. 13: Frank AE, Wingo CS, Andrews PM, Ageloff S, Knepper MA, Weiner ID. Mechanisms through which ammonia regulates cortical collecting duct net proton secretion. Am J Physiol Renal Physiol. 2002 Jun;282(6):F1120-8. PubMed PMID: 11997329. 14: Johnson RG, Meyer RA, Li XR, Preus DM, Tan L, Grunenwald H, Paulson AF, Laird DW, Sheridan JD. Gap junctions assemble in the presence of cytoskeletal inhibitors, but enhanced assembly requires microtubules. Exp Cell Res. 2002 Apr 15;275(1):67-80. PubMed PMID: 11925106. 15: Stumptner C, Fuchsbichler A, Lehner M, Zatloukal K, Denk H. Sequence of events in the assembly of Mallory body components in mouse liver: clues to the pathogenesis and significance of Mallory body formation. J Hepatol. 2001 May;34(5):665-75. PubMed PMID: 11434612. 16: Nery AL, Quina FH, Moreira PF Jr, Medeiros CE, Baader WJ, Shimizu K, Catalani LH, Bechara EJ. Does the photochemical conversion of colchicine into lumicolchicines involve triplet transients? A solvent dependence study. Photochem Photobiol. 2001 Mar;73(3):213-8. PubMed PMID: 11281015. 17: García F, Kierbel A, Larocca MC, Gradilone SA, Splinter P, LaRusso NF, Marinelli RA. The water channel aquaporin-8 is mainly intracellular in rat hepatocytes, and its plasma membrane insertion is stimulated by cyclic AMP. J Biol Chem. 2001 Apr 13;276(15):12147-52. Epub 2001 Jan 17. PubMed PMID: 11278499. 18: Azzam ZS, Saldias FJ, Comellas A, Ridge KM, Rutschman DH, Sznajder JI. Catecholamines increase lung edema clearance in rats with increased left atrial pressure. J Appl Physiol (1985). 2001 Mar;90(3):1088-94. PubMed PMID: 11181624. 19: Lee LJ, Chen JS, Ko TL, Wang SM. Mechanism of colchicine-induced steroidogenesis in rat adrenocortical cells. J Cell Biochem. 2001;81(1):162-71. PubMed PMID: 11180406. 20: Mons S, Veretout F, Carlier M, Erk I, Lepault J, Trudel E, Salesse C, Ducray P, Mioskowski C, Lebeau L. The interaction between lipid derivatives of colchicine and tubulin: consequences of the interaction of the alkaloid with lipid membranes. Biochim Biophys Acta. 2000 Sep 29;1468(1-2):381-95. PubMed PMID: 11018681.