IUPAC/Chemical Name
(5alpha,12beta)-12-(Acetyloxy)-4,4,14-trimethyl-3,7,11,15-tetraoxochol-8-en-24-oic acid
InChi Key
LTJSBYAKDOGXLX-JTJCPSTFSA-N
InChi Code
InChI=1S/C29H38O8/c1-14(8-9-21(34)35)16-12-20(33)29(7)22-17(31)13-18-26(3,4)19(32)10-11-27(18,5)23(22)24(36)25(28(16,29)6)37-15(2)30/h14,16,18,25H,8-13H2,1-7H3,(H,34,35)/t14-,16-,18+,25-,27+,28+,29+/m1/s1
SMILES Code
C[C@H](CCC(O)=O)[C@H]([C@]1([C@@H]2OC(C)=O)C)CC([C@@]1(C)C(C(C[C@@]3([H])C(C)(C)C(CC[C@]43C)=O)=O)=C4C2=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
514.62
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Che XQ, Li SP, Zhao J. [Ganoderma triterpenoids from aqueous extract of Ganoderma lucidum]. Zhongguo Zhong Yao Za Zhi. 2017 May;42(10):1908-1915. doi: 10.19540/j.cnki.cjcmm.20170412.001. Chinese. PubMed PMID: 29090550.
2: Sahoo AK, Dash UC, Kanhar S, Mahapatra AK. In vitro biological assessment of Homalium zeylanicum and isolation of lucidenic acid A triterpenoid. Toxicol Rep. 2017 Jun 4;4:274-281. doi: 10.1016/j.toxrep.2017.04.004. eCollection 2017. PubMed PMID: 28959649; PubMed Central PMCID: PMC5615128.
3: Baby S, Johnson AJ, Govindan B. Secondary metabolites from Ganoderma. Phytochemistry. 2015 Jun;114:66-101. doi: 10.1016/j.phytochem.2015.03.010. Epub 2015 May 11. PubMed PMID: 25975187.
4: Watanabe K, Shuto T, Sato M, Onuki K, Mizunoe S, Suzuki S, Sato T, Koga T, Suico MA, Kai H, Ikeda T. Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK. Biochem Biophys Res Commun. 2011 Apr 29;408(1):18-24. doi: 10.1016/j.bbrc.2011.03.108. Epub 2011 Mar 29. PubMed PMID: 21453678.
5: Iwatsuki K, Akihisa T, Tokuda H, Ukiya M, Oshikubo M, Kimura Y, Asano T, Nomura A, Nishino H. Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation. J Nat Prod. 2003 Dec;66(12):1582-5. PubMed PMID: 14695801.
6: Zhu M, Chang Q, Wong LK, Chong FS, Li RC. Triterpene antioxidants from ganoderma lucidum. Phytother Res. 1999 Sep;13(6):529-31. PubMed PMID: 10479768.
