Synonym
5-FDQD; 5 FDQD; 5FDQD
IUPAC/Chemical Name
5-(3-(4-Fluorophenyl)butyl)-7,8-dimethylpyrido[3,4-b]quinoxaline-1,3(2H,5H)-dione
InChi Key
GZESURGMXLJROO-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H22FN3O2/c1-13(16-4-6-17(24)7-5-16)8-9-27-19-11-15(3)14(2)10-18(19)25-22-20(27)12-21(28)26-23(22)29/h4-7,10-13H,8-9H2,1-3H3,(H,26,28,29)
SMILES Code
O=C(C1=NC2=C(C=C(C)C(C)=C2)N(CCC(C3=CC=C(F)C=C3)C)C1=C4)NC4=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
391.45
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Vicens Q, Mondragón E, Reyes FE, Coish P, Aristoff P, Berman J, Kaur H, Kells KW, Wickens P, Wilson J, Gadwood RC, Schostarez HJ, Suto RK, Blount KF, Batey RT. Structure-Activity Relationship of Flavin Analogues That Target the Flavin Mononucleotide Riboswitch. ACS Chem Biol. 2018 Sep 20. doi: 10.1021/acschembio.8b00533. [Epub ahead of print] PubMed PMID: 30107111.
2: Blount KF, Megyola C, Plummer M, Osterman D, O'Connell T, Aristoff P, Quinn C, Chrusciel RA, Poel TJ, Schostarez HJ, Stewart CA, Walker DP, Wuts PG, Breaker RR. Novel riboswitch-binding flavin analog that protects mice against Clostridium difficile infection without inhibiting cecal flora. Antimicrob Agents Chemother. 2015 Sep;59(9):5736-46. doi: 10.1128/AAC.01282-15. Epub 2015 Jul 13. PubMed PMID: 26169403; PubMed Central PMCID: PMC4538501.
