WAY103 | VLA-4 Antagonist

MedKoo Cat#: 564196 | Name: WAY103

Description:

WARNING: This product is for research use only, not for human or veterinary use.

WAY103 is a very late adhesion molecule 4 (VLA-4) antagonist. It inhibits VLA-4/VCAM-1 ligation as a means of modulating eosinophil functions beyond its action on cell adhesion and migration.

Chemical Structure

WAY103

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564196

Name: WAY103

CAS#: NONE

Chemical Formula: C22H29N5O7S2

Exact Mass: 539.1508

Molecular Weight: 539.62

Elemental Analysis: C, 48.97; H, 5.42; N, 12.98; O, 20.75; S, 11.88

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

WAY-103; WAY 103; WAY103

IUPAC/Chemical Name

(2S)-3-(4-Dimethylcarbamoyloxyphenyl)-2-{[(4R)-5,5-dimethyl-3-(1-methyl-1H-pyrazole-4 sulfonyl)thiazolidine-4-carbonyl]amino}propionic acid

InChi Key

IZHMSLJUKTYUPC-ZWKOTPCHSA-N

InChi Code

InChI=1S/C22H29N5O7S2/c1-22(2)18(27(13-35-22)36(32,33)16-11-23-26(5)12-16)19(28)24-17(20(29)30)10-14-6-8-15(9-7-14)34-21(31)25(3)4/h6-9,11-12,17-18H,10,13H2,1-5H3,(H,24,28)(H,29,30)/t17-,18+/m0/s1

SMILES Code

O=C(O)[C@@H](NC([C@H]1N(S(=O)(C2=CN(C)N=C2)=O)CSC1(C)C)=O)CC3=CC=C(OC(N(C)C)=O)C=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 539.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sedgwick JB, Jansen KJ, Kennedy JD, Kita H, Busse WW. Effects of the very late adhesion molecule 4 antagonist WAY103 on human peripheral blood eosinophil vascular cell adhesion molecule 1-dependent functions. J Allergy Clin Immunol. 2005 Oct;116(4):812-9. Epub 2005 Aug 24. PubMed PMID: 16210055.