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MedKoo Cat#: 581460 | Name: Formebolone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Formebolone also known (confusingly) as formyldienolone, as well as 2-formyl-11α-hydroxy-17α-methyl-δ1-testosterone, is an orally active anabolic-androgenic steroid (AAS) described as an anticatabolic and anabolic drug. Formebolone counteracts the catabolic effects (control of nitrogen balance) of potent glucocorticoids like dexamethasone phosphate. A close analogue, roxibolone (and its long-acting ester variant decylroxibolone), shows similar antiglucocorticoid activity to formebolone but, in contrast, is devoid of activity as an AAS.

Chemical Structure

Formebolone
Formebolone
CAS#2454-11-7

Theoretical Analysis

MedKoo Cat#: 581460

Name: Formebolone

CAS#: 2454-11-7

Chemical Formula: C21H28O4

Exact Mass: 344.1988

Molecular Weight: 344.45

Elemental Analysis: Chemical Formula: C21H28O4 Exact Mass: 344.1988 Molecular Weight: 344.4510 Elemental Analysis: C, 73.23; H, 8.19; O, 18.58

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
No Data
Synonym
Formebolone; Esiclene; Formebolona; Formebolonum; Formyldienolone
IUPAC/Chemical Name
11-alpha,17-beta-Dihydroxy-17-methyl-3-oxoandrosta-1,4-diene-2-carboxaldehyde
InChi Key
AMVODTGMYSRMNP-GNIMZFFESA-N
InChi Code
InChI=1S/C21H28O4/c1-19-9-12(11-22)16(23)8-13(19)4-5-14-15-6-7-21(3,25)20(15,2)10-17(24)18(14)19/h8-9,11,14-15,17-18,24-25H,4-7,10H2,1-3H3/t14-,15-,17+,18+,19-,20-,21-/m0/s1
SMILES Code
C[C@@]12[C@@](C)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(C(C=O)=C[C@]4(C)[C@@]3([H])[C@H](O)C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 344.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pozo OJ, Van Eenoo P, Deventer K, Elbardissy H, Grimalt S, Sancho JV, Hernandez F, Ventura R, Delbeke FT. Comparison between triple quadrupole, time of flight and hybrid quadrupole time of flight analysers coupled to liquid chromatography for the detection of anabolic steroids in doping control analysis. Anal Chim Acta. 2011 Jan 17;684(1-2):98-111. doi: 10.1016/j.aca.2010.10.045. Epub 2010 Nov 9. PubMed PMID: 21167991. 2: Leinonen A, Kuuranne T, Kotiaho T, Kostiainen R. Screening of free 17-alkyl-substituted anabolic steroids in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry. Steroids. 2004 Feb;69(2):101-9. PubMed PMID: 15013688. 3: Cuatrecasas Membrado JM, Bosch Banyeres JM. [Study of non-hypophysiary growth retardation treated with formebolone]. An Esp Pediatr. 1985 Jan;22(1):27-32. Spanish. PubMed PMID: 3985494. 4: Sperandeo F, Pedrazzini S, De Marchi G, Marre E. [Study on potential and real impurities present in a synthetic steroid: formebolone]. Boll Chim Farm. 1979 Apr;118(4):200-21. Italian. PubMed PMID: 454541. 5: Pestalardi RV, Vàsquez OA, de Bujovic AT. [Effect of Formebolone in 16 infants with malnutrition]. Minerva Pediatr. 1977 Feb 18;29(5):297-302. Italian. PubMed PMID: 854006. 6: Gomarasca P, D'atri G, Cerutti S, Pedrazzini S. [Nitrogen balance in rats treated with Formebolone]. Boll Chim Farm. 1976 Dec;114(12):714-29. Italian. PubMed PMID: 1267976. 7: Galimberti E, Forlani A. [Interaction of formebolone and natural cortico-adrenal extracts]. Boll Chim Farm. 1976 Sep;115(9):638-43. Italian. PubMed PMID: 1016618. 8: Cerutti S, Forlani A, Galimberti E. Anticatabolic action of formebolone in the castrated rat treated with dexamethasone. Arzneimittelforschung. 1976;26(9):1673-7. PubMed PMID: 1036699. 9: Gelli D, Vignati E. Metabolic studies with formebolone (2-formyl-17 (alpha)-methyl-androsta-1,4-diene-11 (alpha), 17 (beta)-diol-3-one) in humans. J Int Med Res. 1976;4(2):96-105. PubMed PMID: 799985. 10: Esposito R, Pluvio M, Giordano D. Anabolic agents in kidney disease: the effect of formebolone on protein synthesis in patients with renal insufficiency or nephrosis. Curr Med Res Opin. 1975;3(1):43-5. PubMed PMID: 1116383. 11: D'Atri G, Galimberti E, Gomarasca P. [Increase of tissue enzyme activity induced by formyldienolone. 3. Alkaline phosphatase]. Boll Chim Farm. 1973 Sep;112(9):620-31. Italian. PubMed PMID: 4786709. 12: Galimberti E, D'Atri G, Cerutti S. [Increased enzymatic activity induced by formyldienolone. II. Diaphorase]. Boll Chim Farm. 1973;112(6):370-8. Italian. PubMed PMID: 4767639. 13: Gomarasca P, Galimberti E, Cerutti S. [Increased enzymatic activity induced by formyldienolone. I. Succinate dehydrogenase]. Boll Chim Farm. 1972 Dec;111(12):731-9. Italian. PubMed PMID: 4656465. 14: Cornet F, Pedrazzini S. [Formyldienolone]. Boll Chim Farm. 1972 Nov;111(11):645-8. Italian. PubMed PMID: 4655668.