SGC-GAK-1N | CAS# 2226517-74-2 | Negative Control for SGC-GAK-1

MedKoo Cat#: 564185 | Name: SGC-GAK-1N

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SGC-GAK-1N is a negative control for SGC-GAK-1.

Chemical Structure

SGC-GAK-1N

CAS# 2226517-74-2

Theoretical Analysis

MedKoo Cat#: 564185

Name: SGC-GAK-1N

CAS#: 2226517-74-2

Chemical Formula: C20H19F3N2O3

Exact Mass: 392.1348

Molecular Weight: 392.38

Elemental Analysis: C, 61.22; H, 4.88; F, 14.53; N, 7.14; O, 12.23

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 300.00	2 weeks
25mg	USD 650.00	2 weeks

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Synonym

SGCGAK1N; SGC GAK 1N; SGC-GAK-1N; SGCGAK-1N; SGC-GAK1N

IUPAC/Chemical Name

N-Methyl-6-(trifluoromethyl)-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine

InChi Key

PVTQCCFMFWASHK-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H19F3N2O3/c1-25(13-10-17(26-2)19(28-4)18(11-13)27-3)16-7-8-24-15-6-5-12(9-14(15)16)20(21,22)23/h5-11H,1-4H3

SMILES Code

COC1=C(OC)C(OC)=CC(N(C)C2=CC=NC3=CC=C(C(F)(F)F)C=C23)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot# S21G11M01

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

SGC-GAK-1 is a high affinity GAK inhibitor (Kd = 1.9 nM) and exhibits >30-fold selectivity for GAK over a panel of other kinases. SGC-GAK-1 inhibits GAK in live cell assays (IC50 = 110 nM).

In vitro activity:

This article describes SGC-GAK-1 and the structurally related negative control SGC-GAK-1N. Reference: J Med Chem. 2019 Mar 14;62(5):2830-2836. https://pubmed.ncbi.nlm.nih.gov/30768268/

In vivo activity:

To be determined

	Solvent	mg/mL	mM	comments
Solubility
	DMSO	2.0	5.10

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 392.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Asquith CRM, Berger BT, Wan J, Bennett JM, Capuzzi SJ, Crona DJ, Drewry DH, East MP, Elkins JM, Fedorov O, Godoi PH, Hunter DM, Knapp S, Müller S, Torrice CD, Wells CI, Earp HS, Willson TM, Zuercher WJ. SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). J Med Chem. 2019 Mar 14;62(5):2830-2836. doi: 10.1021/acs.jmedchem.8b01213. Epub 2019 Feb 26. PMID: 30768268; PMCID: PMC6567991.

In vitro protocol:

In vivo protocol: