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MedKoo Cat#: 341608 | Name: Methazole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Methazole also known as methimazole, is an antithyroid drug,[2] and part of the thioamide group.

Chemical Structure

Methazole
Methazole
CAS#20354-26-1

Theoretical Analysis

MedKoo Cat#: 341608

Name: Methazole

CAS#: 20354-26-1

Chemical Formula: C9H6Cl2N2O3

Exact Mass: 259.9755

Molecular Weight: 261.06

Elemental Analysis: C, 41.41; H, 2.32; Cl, 27.16; N, 10.73; O, 18.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Methazole; VCS 438; VCS-438; VCS438.
IUPAC/Chemical Name
2-(3,4-Dichlorophenyl)-4-methyl-1,2,4-oxadiazolidine-3,5-dione
InChi Key
LRUUNMYPIBZBQH-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H6Cl2N2O3/c1-12-8(14)13(16-9(12)15)5-2-3-6(10)7(11)4-5/h2-4H,1H3
SMILES Code
O=C(N1C)N(C2=CC=C(Cl)C(Cl)=C2)OC1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 261.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Phisalprapa P, Supakankunti S, Charatcharoenwitthaya P, Apisarnthanarak P, Charoensak A, Washirasaksiri C, Srivanichakorn W, Chaiyakunapruk N. Cost-effectiveness analysis of ultrasonography screening for nonalcoholic fatty liver disease in metabolic syndrome patients. Medicine (Baltimore). 2017 Apr;96(17):e6585. doi: 10.1097/MD.0000000000006585. PubMed PMID: 28445256; PubMed Central PMCID: PMC5413221. 2: To K. Boltzmann distribution in a nonequilibrium steady state: measuring local potential by granular Brownian particles. Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Jun;89(6):062111. Epub 2014 Jun 9. PubMed PMID: 25019729. 3: Wilczyńska-Piliszek AJ, Piliszek S, Falandysz J. Use of quantitative-structure property relationship (QSPR) and artificial neural network (ANN) based approaches for estimating the octanol-water partition coefficients of the 209 chlorinated trans-azobenzene congeners. J Environ Sci Health B. 2012;47(2):111-28. doi: 10.1080/03601234.2012.616779. PubMed PMID: 22251211. 4: Zhang HY, Shi HY, Wang EY. [Effect of environment temperature on the recovery of microdialysis probe for monoamine neurotransmitter]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2009 May;38(3):271-5. Chinese. PubMed PMID: 19504636. 5: Diallo IS, Hewitson G, Wright L, Rodwell BJ, Corney BG. Detection of equine herpesvirus type 1 using a real-time polymerase chain reaction. J Virol Methods. 2006 Jan;131(1):92-8. Epub 2005 Aug 30. PubMed PMID: 16137772. 6: Singh TD, Sumitra Ch, Yaiphaba N, Devi HD, Devi MI, Singh NR. Comparison of energy interaction parameters for the complexation of Pr(III) with glutathione reduced (GSH) in absence and presence of Zn(II) in aqueous and aquated organic solvents using 4f-4f transition spectra as PROBE. Spectrochim Acta A Mol Biomol Spectrosc. 2005 Apr;61(6):1219-25. PubMed PMID: 15741124. 7: Kuljanishvili I, Chakraborty S, Maasilta IJ, Tessmer SH, Melloch MR. Modeling electric-field-sensitive scanning probe measurements for a tip of arbitrary shape. Ultramicroscopy. 2004 Dec;102(1):7-12. PubMed PMID: 15556695. 8: Fonseca L, Pérez-Murano F, Calaza C, Rubio R, Santander J, Figueras E, Gràcia I, Cané C, Moreno M, Marco S. Thermal AFM: a thermopile case study. Ultramicroscopy. 2004 Nov;101(2-4):153-9. PubMed PMID: 15450661. 9: Laube N, Jansen B, Schneider A, Steffes HJ, Hesse A. Hippuric acid as a modifier of calcium oxalate crystallisation. Clin Chem Lab Med. 2001 Mar;39(3):218-22. PubMed PMID: 11350018. 10: Suzuki T, Casida JE. Metabolites of diuron, linuron, and methazole formed by liver microsomal enzymes and spinach plants. J Agric Food Chem. 1981 Sep-Oct;29(5):1027-33. PubMed PMID: 7309986. 11: Moubasher AH, El-Hissy FT, Abdel-Kader MI. Selective effects of three herbicides on the fungus flora of Egyptian soil. Folia Microbiol (Praha). 1981;26(1):37-44. PubMed PMID: 7203286. 12: Horowitz M. Herbicidal treatments for control of Papaver somniferum L. Bull Narc. 1980;32(1):33-43. PubMed PMID: 6905769. 13: Kimbrough RD. Human health effects of selected pesticides, chloroaniline derivatives. J Environ Sci Health B. 1980;15(6):977-92. PubMed PMID: 6449525. 14: Horowitz M. Herbicidal treatments for control of Cannabis sativa L. Bull Narc. 1977 Jan-Mar;29(1):75-84. PubMed PMID: 585583. 15: Atallah YH, Whitacre DM, Dorough HW. Metabolism of the herbicide methazole in lactating cows and laying hens. J Agric Food Chem. 1976 Sep-Oct;24(5):1007-12. PubMed PMID: 965584. 16: Dorough HW. Metabolism of methazole in wheat and onions. Bull Environ Contam Toxicol. 1974 Oct;12(4):493-500. PubMed PMID: 4433895. 17: Dorough HW, Whitacre DM, Cardona RA. Metabolism of the herbicide methazole in cotton and beans, and fate of certain of its polar metabolites in rats. J Agric Food Chem. 1973 Sep-Oct;21(5):797-803. PubMed PMID: 4733371. 18: Ivie GW, Dorough HW, Cardona RA. Photodecomposition of the herbicide methazole. J Agric Food Chem. 1973 May-Jun;21(3):386-91. PubMed PMID: 4708799.

View History

BETi-211

BETi-211