Gpr52 antagonist E7 | CAS# 185213-52-9 | Gpr52 Antagonist

MedKoo Cat#: 564156 | Name: Gpr52 antagonist E7

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Gpr52 antagonist E7 is a Gpr52 antagonist. It reduces mutant HTT levels and rescues Huntington’s disease-associated phenotypes in cellular and mouse models.

Chemical Structure

Gpr52 antagonist E7

CAS#185213-52-9

Theoretical Analysis

MedKoo Cat#: 564156

Name: Gpr52 antagonist E7

CAS#: 185213-52-9

Chemical Formula: C20H22O6

Exact Mass: 358.1416

Molecular Weight: 358.39

Elemental Analysis: C, 67.03; H, 6.19; O, 26.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Gpr 52 antagonist E7; Gpr-52 antagonist E7; Gpr52 antagonist E7

IUPAC/Chemical Name

(3S,4R,8R,9E)-10-methyl-5-methylidene-6,14-dioxo-7,13-dioxatricyclo[10.2.1.0(4,8)]pentadeca-1(15),9-dien-3-yl (2Z)-2-methylbut-2-enoate

InChi Key

FTPHYXGWMIZVMP-UGZAWPFQSA-N

InChi Code

InChI=1S/C20H22O6/c1-5-11(3)18(21)25-16-9-13-8-14(24-20(13)23)6-10(2)7-15-17(16)12(4)19(22)26-15/h5,7-8,14-17H,4,6,9H2,1-3H3/b10-7+,11-5-/t14?,15-,16+,17+/m1/s1

SMILES Code

C/C=C(C)\C(O[C@H]([C@@]1([H])C2=C)CC3=CC(OC3=O)C/C(C)=C/[C@@]1([H])OC2=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 358.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Song H, Li H, Guo S, Pan Y, Fu Y, Zhou Z, Li Z, Wen X, Sun X, He B, Gu H, Zhao Q, Wang C, An P, Luo S, Hu Y, Xie X, Lu B. Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes. Brain. 2018 Jun 1;141(6):1782-1798. doi: 10.1093/brain/awy081. PubMed PMID: 29608652; PubMed Central PMCID: PMC5972579.