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MedKoo Cat#: 564128 | Name: L82-G17
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

L82-G17 is a selective uncompetitive inhibitor of DNA ligase I (LigI).

Chemical Structure

L82-G17
L82-G17
CAS#92285-87-5

Theoretical Analysis

MedKoo Cat#: 564128

Name: L82-G17

CAS#: 92285-87-5

Chemical Formula: C11H9ClN4O2

Exact Mass: 264.0414

Molecular Weight: 264.67

Elemental Analysis: C, 49.92; H, 3.43; Cl, 13.39; N, 21.17; O, 12.09

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
1g USD 3,950.00 2 Weeks
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Related CAS #
No Data
Synonym
L82-G17; L82G17; L82 G17
IUPAC/Chemical Name
4-Chloro-5-{2-[(3-hydroxyphenyl)methylidene]hydrazin-1-yl}-2,3-dihydropyridazin-3-one
InChi Key
PYYWVUBALUMAIY-WLRTZDKTSA-N
InChi Code
InChI=1S/C11H9ClN4O2/c12-10-9(6-14-16-11(10)18)15-13-5-7-2-1-3-8(17)4-7/h1-6,17H,(H2,15,16,18)/b13-5+
SMILES Code
O=C1C(Cl)=C(N/N=C/C2=CC=CC(O)=C2)C=NN1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor.
In vitro activity:
Among the LigI-selective inhibitors, L82-G17 exhibited increased activity against and selectivity for LigI compared with L82. Notably. L82-G17 is an uncompetitive inhibitor of the third step of the ligation reaction, phosphodiester bond formation. Cells expressing LigI were more sensitive to L82-G17 than isogenic LIG1 null cells. Reference: DNA Repair (Amst). 2017 Dec;60:29-39. https://pubmed.ncbi.nlm.nih.gov/29078112/
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 125.0 472.29
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 264.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Howes TRL, Sallmyr A, Brooks R, Greco GE, Jones DE, Matsumoto Y, Tomkinson AE. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 Dec;60:29-39. doi: 10.1016/j.dnarep.2017.10.002. Epub 2017 Oct 10. Erratum in: DNA Repair (Amst). 2017 Dec 19;: PMID: 29078112; PMCID: PMC5881949.
In vitro protocol:
1. Howes TRL, Sallmyr A, Brooks R, Greco GE, Jones DE, Matsumoto Y, Tomkinson AE. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 Dec;60:29-39. doi: 10.1016/j.dnarep.2017.10.002. Epub 2017 Oct 10. Erratum in: DNA Repair (Amst). 2017 Dec 19;: PMID: 29078112; PMCID: PMC5881949.
In vivo protocol:
TBD
1: Howes TRL, Sallmyr A, Brooks R, Greco GE, Jones DE, Matsumoto Y, Tomkinson AE. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 Dec;60:29-39. doi: 10.1016/j.dnarep.2017.10.002. Epub 2017 Oct 10. Erratum in: DNA Repair (Amst). 2017 Dec 19;:. PubMed PMID: 29078112; PubMed Central PMCID: PMC5881949.

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