MedKoo Cat#: 564123 | Name: VFN38826
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VFN38826, also known as CDK8-IN-4, is a CDK8 inhibitor. VFN38826 was first reported in patent WO2014090692A1, compound example 16, with an IC50 of 0.2 nM. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

VFN38826
VFN38826
CAS#1613638-82-6

Theoretical Analysis

MedKoo Cat#: 564123

Name: VFN38826

CAS#: 1613638-82-6

Chemical Formula: C20H18N4O

Exact Mass: 330.1481

Molecular Weight: 330.39

Elemental Analysis: C, 72.71; H, 5.49; N, 16.96; O, 4.84

Price and Availability

Size Price Availability Quantity
5mg USD 500.00 2 Weeks
10mg USD 800.00 2 Weeks
25mg USD 1,300.00 2 Weeks
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Related CAS #
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Synonym
CDK8-IN-4, VFN38826; VFN-38826; VFN 38826;
IUPAC/Chemical Name
(R)-2-((5-(1H-indazol-5-yl)pyridin-3-yl)amino)-2-phenylethan-1-ol; (2R)-2-[[5-(1H-Indazol-5-yl)pyridin-3-yl]amino]-2-phenylethanol
InChi Key
VFKCKMKPKIUZOF-FQEVSTJZSA-N
InChi Code
InChI=1S/C20H18N4O/c25-13-20(14-4-2-1-3-5-14)23-18-9-16(10-21-12-18)15-6-7-19-17(8-15)11-22-24-19/h1-12,20,23,25H,13H2,(H,22,24)/t20-/m0/s1
SMILES Code
OC[C@H](NC1=CC(C2=CC3=C(NN=C3)C=C2)=CN=C1)C4=CC=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 330.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Xie, X. J., Hsu, F. N., Gao, X., Xu, W., Ni, J. Q., Xing, Y., ... & Ji, J. Y. (2015). CDK8-cyclin C mediates nutritional regulation of developmental transitions through the ecdysone receptor in Drosophila. PLoS biology, 13(7), e1002207. Xu, W., Xie, X. J., Faust, A. K., Liu, M., Li, X., Chen, F., ... & Ji, J. Y. (2020). All-Atomic molecular dynamic studies of human and drosophila CDK8: insights into their kinase domains, the LXXLL motifs, and drug binding site. International journal of molecular sciences, 21(20), 7511.