CAY10678, also known as C3 and mPGES-1 Inhibitor III, is a selective microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor. CAY10678 potently inhibits human and rat recombinant mPGES-1 (IC50 = 0.09 and 0.9 µM, respectively). It has minimal effects on COX-1, COX-2, PGIS, and hematopoietic PGDS at 50 μM but reduces lipocalin-type PGDS activity by 60% at this concentration.
MedKoo Cat#: 584584
Name: CAY10678
CAS#: 1268709-57-4
Chemical Formula: C23H34N4O
Exact Mass: 382.2733
Molecular Weight: 382.55
Elemental Analysis: C, 72.21; H, 8.96; N, 14.65; O, 4.18
The following data is based on the product molecular weight 382.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
