MedKoo Cat#: 584583 | Name: 1M7
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

1M7 is a reagent for RNA SHAPE-MaP experiments that enables analysis of RNA secondary structures at single nucleotide resolution in <70 seconds.

Chemical Structure

1M7
1M7
CAS#73043-80-8

Theoretical Analysis

MedKoo Cat#: 584583

Name: 1M7

CAS#: 73043-80-8

Chemical Formula: C9H6N2O5

Exact Mass: 222.0277

Molecular Weight: 222.16

Elemental Analysis: C, 48.66; H, 2.72; N, 12.61; O, 36.01

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
250mg USD 1,450.00 2 Weeks
1g USD 3,250.00 2 Weeks
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Related CAS #
No Data
Synonym
1M7
IUPAC/Chemical Name
1-Methyl-7-nitro-2H-3,1-benzoxazine-2,4(1H)-dione
InChi Key
MULNCJWAVSDEKJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H6N2O5/c1-10-7-4-5(11(14)15)2-3-6(7)8(12)16-9(10)13/h2-4H,1H3
SMILES Code
O=C(O1)N(C)C2=CC([N+]([O-])=O)=CC=C2C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 222.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Mortimer et al (2007) A fast-acting reagent for accurate analysis of RNA secondary and tertiary structure by SHAPE chemistry. J.Am.Chem.Soc. 129 4144 PMID: 17367143 Turner et al (2013) Safer one-pot synthesis of the 'SHAPE' reagent 1-methyl-7-nitroisatoic anhydride (1m7). RNA 19 1857 PMID: 24141619 Siegfried et al (2014) RNA motif discovery by SHAPE and mutational profiling (SHAPE-MaP). Nat.Methods 11 959 PMID: 25028896 Smola et al (2015) Detection of RNA-Protein interactions in living cells with SHAPE. Biochemistry 54 6867 PMID: 26544910