KCC 07 | CAS#315702-75-1 | MBD2 inhibitor

MedKoo Cat#: 584581 | Name: KCC 07

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

KCC 07 is an MBD2 (Methyl-CpG-binding domain protein 2) inhibitor that prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling.

Chemical Structure

KCC 07

CAS#315702-75-1

Theoretical Analysis

MedKoo Cat#: 584581

Name: KCC 07

CAS#: 315702-75-1

Chemical Formula: C14H11N3OS

Exact Mass: 269.0623

Molecular Weight: 269.32

Elemental Analysis: C, 62.44; H, 4.12; N, 15.60; O, 5.94; S, 11.90

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 350.00	2 Weeks
50mg	USD 850.00	2 Weeks

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Related CAS #

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Synonym

KCC 07; KCC07; KCC-07

IUPAC/Chemical Name

3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol

InChi Key

GIGNWEDIMLUWCT-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H11N3OS/c18-11-5-3-4-10(8-11)16-14-17-13(9-19-14)12-6-1-2-7-15-12/h1-9,18H,(H,16,17)

SMILES Code

OC1=CC=CC(NC2=NC(C3=NC=CC=C3)=CS2)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

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Product Data

Product Data

Instruction

View handling instruction

Biological target:

KCC-07 is a potent, selective and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor.

In vitro activity:

Moreover, treatment of BAI1-silent MB cells with KCC-07 largely abrogated MBD2 binding to the ADGRB1 promoter (Figure 6D) and restored BAI1 mRNA and protein expression (Figures 6E and 6F) at low concentrations. KCC-07 also clearly inhibited MB cell growth in vitro (Figure 6G), consistent with induction of anti-proliferative BAI1/p53/p21 signaling (Figure 6F). Reference: Cancer Cell. 2018 Jun 11;33(6):1004-1016.e5. https://pubmed.ncbi.nlm.nih.gov/29894688/

In vivo activity:

Fourteen days after MB cell implantation in the cerebellum, mice were treated intraperitoneally (i.p.) with KCC-07. The drug increased median survival in both models: from 22.5 to 29 days (p<0.0001) in D556 xenografts (Figure 7A), and 25.5 to 30 days (p=0.0054) in D425 xenografts (Figure S6A). Tumor size was reduced, and reactivation of BAI1 expression along with augmented nuclear p53 was detected in the KCC-07 group (Figure 7B). Reference: Cancer Cell. 2018 Jun 11;33(6):1004-1016.e5. https://pubmed.ncbi.nlm.nih.gov/29894688/

	Solvent	mg/mL	mM
Solubility
	DMSO	68.6	254.87
	Ethanol	29.7	110.26

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 269.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Zhu D, Osuka S, Zhang Z, Reichert ZR, Yang L, Kanemura Y, Jiang Y, You S, Zhang H, Devi NS, Bhattacharya D, Takano S, Gillespie GY, Macdonald T, Tan C, Nishikawa R, Nelson WG, Olson JJ, Van Meir EG. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation. Cancer Cell. 2018 Jun 11;33(6):1004-1016.e5. doi: 10.1016/j.ccell.2018.05.006. PMID: 29894688; PMCID: PMC6002773.

In vitro protocol:

In vivo protocol:

Zhu et al (2018) BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation. Cancer Cell 33 1004 PMID: 29894688