MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 407932 | Name: CM39

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CM39 is an ALDH inhibitor. Aldehyde dehydrogenase (ALDH) activity is commonly used as a marker to identify cancer stem-like cells. The three ALDH1A isoforms have all been individually implicated in cancer stem-like cells and in chemoresistance.

Chemical Structure

CM39
CM39
CAS#361156-54-9

Theoretical Analysis

MedKoo Cat#: 407932

Name: CM39

CAS#: 361156-54-9

Chemical Formula: C19H15FN4OS

Exact Mass: 366.0951

Molecular Weight: 366.41

Elemental Analysis: C, 62.28; H, 4.13; F, 5.18; N, 15.29; O, 4.37; S, 8.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
CM39; CM-39; CM 39;
IUPAC/Chemical Name
6-((3-Fluorobenzyl)thio)-5-(o-tolyl)-1H-pyrazolo[3,4-d]-pyrimidin-4(5H)-one
InChi Key
SSEVBNPAVKLWFQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H15FN4OS/c1-12-5-2-3-8-16(12)24-18(25)15-10-21-23-17(15)22-19(24)26-11-13-6-4-7-14(20)9-13/h2-10H,11H2,1H3,(H,21,23)
SMILES Code
O=C1C2=C(NN=C2)N=C(SCC3=CC=CC(F)=C3)N1C4=CC=CC=C4C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 366.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy Brandt C. Huddle, Edward Grimley, Cameron D. Buchman, Mikhail Chtcherbinine, Bikash Debnath, Pooja Mehta, Kun Yang, Cynthia A. Morgan, Siwei Li, Jeremy Felton, Duxin Sun, Geeta Mehta, Nouri Neamati, Ronald J. Buckanovich, Thomas D. Hurley, and Scott D. Larsen Publication Date (Web): September 17, 2018 (Article) DOI: 10.1021/acs.jmedchem.8b00930