GPA512 | CAS# 1808115-35-6 | STAT3 Inhibitor

MedKoo Cat#: 564039 | Name: GPA512

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GPA512 is a prodrug of aliellalactone, inhibiting STAT3 and preventing the transcription of STAT3 regulated genes.

Chemical Structure

GPA512

CAS#1808115-35-6

Theoretical Analysis

MedKoo Cat#: 564039

Name: GPA512

CAS#: 1808115-35-6

Chemical Formula: C17H25NO6S

Exact Mass: 371.1403

Molecular Weight: 371.45

Elemental Analysis: C, 54.97; H, 6.78; N, 3.77; O, 25.84; S, 8.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

GPA512; GPA-512; GPA 512

IUPAC/Chemical Name

methyl N-acetyl-S-((2aR,2a1S,4aR,6S,7R)-2a1-hydroxy-6-methyl-1-oxodecahydroindeno[1,7-bc]furan-7-yl)-L-cysteinate

InChi Key

QXOOJZPKZHXIHX-VZRFOGRKSA-N

InChi Code

InChI=1S/C17H25NO6S/c1-8-6-10-4-5-12-17(10,22)13(16(21)24-12)14(8)25-7-11(15(20)23-3)18-9(2)19/h8,10-14,22H,4-7H2,1-3H3,(H,18,19)/t8-,10+,11-,12+,13?,14+,17+/m0/s1

SMILES Code

C[C@H]1C[C@@H](CC[C@H]2OC3=O)[C@]2(O)C3[C@@H]1SC[C@H](NC(C)=O)C(OC)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 371.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Escobar Z, Bjartell A, Canesin G, Evans-Axelsson S, Sterner O, Hellsten R, Johansson MH. Preclinical Characterization of 3β-(N-Acetyl l-cysteine methyl ester)-2aβ,3-dihydrogaliellalactone (GPA512), a Prodrug of a Direct STAT3 Inhibitor for the Treatment of Prostate Cancer. J Med Chem. 2016 May 26;59(10):4551-62. doi: 10.1021/acs.jmedchem.5b01814. Epub 2016 May 3. PubMed PMID: 27111731.