IQDMA | CAS# 401463-02-3 | STAT5 Inhibitor

MedKoo Cat#: 564031 | Name: IQDMA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IQDMA is an inhibitor of the transcription factor STAT5.

Chemical Structure

IQDMA

CAS#401463-02-3

Theoretical Analysis

MedKoo Cat#: 564031

Name: IQDMA

CAS#: 401463-02-3

Chemical Formula: C19H20N4

Exact Mass: 304.1688

Molecular Weight: 304.40

Elemental Analysis: C, 74.97; H, 6.62; N, 18.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

C524250; IQDMA cpd; IQDMA

IUPAC/Chemical Name

N'-(11H-Indolo[3,2-c]quinolin-6-yl)-N,N-dimethylethane-1,2-diamine

InChi Key

UROLFQZUYMCOHV-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H20N4/c1-23(2)12-11-20-19-17-13-7-3-5-9-15(13)21-18(17)14-8-4-6-10-16(14)22-19/h3-10,21H,11-12H2,1-2H3,(H,20,22)

SMILES Code

CN(C)CCNC1=NC2=CC=CC=C2C3=C1C4=C(N3)C=CC=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 304.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Su JC, Lin KL, Chien CM, Lu CM, Chen YL, Chang LS, Lin SR. Novel indoloquinoline derivative, IQDMA, induces G(2)/M phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation. Life Sci. 2009 Sep 23;85(13-14):505-16. doi: 10.1016/j.lfs.2009.08.006. Epub 2009 Aug 21. PubMed PMID: 19699753. 2: Yang SH, Chien CM, Su JC, Chen YL, Chang LS, Lin SR. Novel indoloquinoline derivative, IQDMA, inhibits STAT5 signaling associated with apoptosis in K562 cells. J Biochem Mol Toxicol. 2008 Nov-Dec;22(6):396-404. doi: 10.1002/jbt.20254. PubMed PMID: 19111001. 3: Chien CM, Yang SH, Lin KL, Chen YL, Chang LS, Lin SR. Novel indoloquinoline derivative, IQDMA, suppresses STAT5 phosphorylation and induces apoptosis in HL-60 cells. Chem Biol Interact. 2008 Oct 22;176(1):40-7. doi: 10.1016/j.cbi.2008.06.008. Epub 2008 Jun 28. PubMed PMID: 18638462. 4: Yang SH, Chien CM, Lu CM, Chen YL, Chang LS, Lin SR. Involvement of c-Jun N-terminal kinase in G2/M arrest and FasL-mediated apoptosis induced by a novel indoloquinoline derivative, IQDMA, in K562 cells. Leuk Res. 2007 Oct;31(10):1413-20. Epub 2007 Mar 29. PubMed PMID: 17397922. 5: Hu XW, Chien CM, Yang SH, Lin YH, Lu CM, Chen YL, Lin SR. A novel indoloquinoline derivative, IQDMA, induces S-phase arrest and apoptosis in promyelocytic leukemia HL-60 cells. Cell Biol Toxicol. 2006 Nov;22(6):417-27. Epub 2006 Aug 13. PubMed PMID: 16906476.