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MedKoo Cat#: 584570 | Name: Lumin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lumin is a cyanine dye that enhances interleukin 12-dependent interferon gamma production by lipopolysaccharide-stimulated mouse splenocytes.

Chemical Structure

Lumin
Lumin
CAS#80893-93-2

Theoretical Analysis

MedKoo Cat#: 584570

Name: Lumin

CAS#: 80893-93-2

Chemical Formula: C38H37Cl2N3

Exact Mass: 605.2365

Molecular Weight: 606.64

Elemental Analysis: C, 75.24; H, 6.15; Cl, 11.69; N, 6.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Lumin
IUPAC/Chemical Name
Quinolinium, 4,4'-(3-((1-ethyl-4(1H)-quinolinylidene)ethylidene)-1-propene-1,3-diyl)bis(1-ethyl-, dichloride
InChi Key
KBRCYOYPZIZVJX-UHFFFAOYSA-L
InChi Code
InChI=1S/C38H37N3.2ClH/c1-4-39-26-23-30(33-13-7-10-16-36(33)39)21-19-29(32-25-28-41(6-3)38-18-12-9-15-35(32)38)20-22-31-24-27-40(5-2)37-17-11-8-14-34(31)37;;/h7-28H,4-6H2,1-3H3;2*1H/q+2;;/p-2
SMILES Code
CCN1C=C/C(C2=C1C=CC=C2)=C\C=C(C3=C4C=CC=CC4=[N+](CC)C=C3)\C=C\C5=C6C=CC=CC6=[N+](CC)C=C5.[Cl-].[Cl-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 606.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yamamoto N, Homma S, Nakagawa Y, Hayami M, Imanaga H, Kurimoto M, Mitsuhashi M, Kimoto T. Activation of mouse macrophages by in vivo and in vitro treatment with a cyanine dye, lumin. J Photochem Photobiol B. 1992 May 15;13(3-4):295-306. PubMed PMID: 1506993. 2: Kunikata T, Ishihara T, Ushio S, Iwaki K, Ikeda M, Kurimoto M. Lumin, a cyanine dye, enhances interleukin 12-dependent interferon gamma production by lipopolysaccharide-stimulated mouse splenocytes. Biol Pharm Bull. 2002 Aug;25(8):1018-21. PubMed PMID: 12186401. 3: Mito K. A needle type therapeutic system incorporating laser light and lumin for immunotherapy of cancer growing in deep organs. J Med Eng Technol. 1996 May-Jun;20(3):121-6. PubMed PMID: 8877753. 4: Mito K. Photodynamic efficiency of macrophage activity using a photosensitizer, lumin, with near-IR laser light for photoimmunotherapy of a cancer. Front Med Biol Eng. 1996;7(2):81-92. PubMed PMID: 8803558. 5: Ushio C, Ariyasu H, Ariyasu T, Arai S, Ohta T, Fukuda S. Suppressive effects of a cyanine dye against herpes simplex virus (HSV)-1 infection. Biomed Res. 2009 Dec;30(6):365-8. PubMed PMID: 20051646. 6: Trusov A, Bumgarner R, Valijev R, Chestnova R, Talevski S, Vragoterova C, Neeley ES. Comparison of Lumin LED fluorescent attachment, fluorescent microscopy and Ziehl-Neelsen for AFB diagnosis. Int J Tuberc Lung Dis. 2009 Jul;13(7):836-41. PubMed PMID: 19555532. 7: Vafaee F, Rakhshan V, Vafaei M, Khoshhal M. Accuracy of shade matching performed by colour blind and normal dental students using 3D Master and Vita Lumin shade guides. Eur J Prosthodont Restor Dent. 2012 Mar;20(1):23-5. PubMed PMID: 22474932. 8: Sasaki Y, Nagai N, Okimura T. [Immunopharmacological actions of lumin (II): Effect of lumin administration in NZB X NZW (B/W) F1 mice]. Nihon Yakurigaku Zasshi. 1987 Jan;89(1):9-13. Japanese. PubMed PMID: 2952570. 9: Sasaki Y, Nagai N, Okimura T, Yamamoto I. [Immunopharmacological actions of lumin (I): Anti-allergic actions of lumin]. Nihon Yakurigaku Zasshi. 1987 Jan;89(1):1-7. Japanese. PubMed PMID: 3570101. 10: Turusov AA, Valiev RSh, Chesnokova RV. [Comparative study of microscopy by the Ziehl Neelsen method, routine fluorescence microscopy, and fluorescence microscopy using a lumin attachment in the diagnosis of acid-resistant mycobacteria]. Probl Tuberk Bolezn Legk. 2009;(4):41-5. Russian. PubMed PMID: 19514454. 11: Li Q, Yu H, Wang YN. Spectrophotometric evaluation of the optical influence of core build-up composites on all-ceramic materials. Dent Mater. 2009 Feb;25(2):158-65. doi: 10.1016/j.dental.2008.05.008. Epub 2008 Jul 7. PubMed PMID: 18606444. 12: Yap AU, Sim CP, Loh WL, Teo JH. Human-eye versus computerized color matching. Oper Dent. 1999 Nov-Dec;24(6):358-63. PubMed PMID: 10823085. 13: Senga K, Mostov KE, Mitaka T, Miyajima A, Tanimizu N. Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25. Mol Biol Cell. 2012 Aug;23(15):2845-55. doi: 10.1091/mbc.E12-02-0097. Epub 2012 Jun 13. PubMed PMID: 22696678; PubMed Central PMCID: PMC3408412. 14: Turnbull ER, Kaunda K, Harris JB, Kapata N, Muvwimi MW, Kruuner A, Henostroza G, Reid SE. An evaluation of the performance and acceptability of three LED fluorescent microscopes in Zambia: lessons learnt for scale-up. PLoS One. 2011;6(11):e27125. doi: 10.1371/journal.pone.0027125. Epub 2011 Nov 4. PubMed PMID: 22073271; PubMed Central PMCID: PMC3208552. 15: Bayindir F, Kuo S, Johnston WM, Wee AG. Coverage error of three conceptually different shade guide systems to vital unrestored dentition. J Prosthet Dent. 2007 Sep;98(3):175-85. PubMed PMID: 17854618; PubMed Central PMCID: PMC2001247. 16: Hammad IA. Intrarater repeatability of shade selections with two shade guides. J Prosthet Dent. 2003 Jan;89(1):50-3. PubMed PMID: 12589286. 17: Lee KY, Setchell D, Stokes A, Moles DR. Brightness (value) sequence for the Vita Lumin Classic shade guide reassessed. Eur J Prosthodont Restor Dent. 2005 Sep;13(3):115-8. PubMed PMID: 16180636. 18: Rodrigues S, Shetty SR, Prithviraj DR. An evaluation of shade differences between natural anterior teeth in different age groups and gender using commercially available shade guides. J Indian Prosthodont Soc. 2012 Dec;12(4):222-30. doi: 10.1007/s13191-012-0134-9. Epub 2012 Jun 22. PubMed PMID: 24293919; PubMed Central PMCID: PMC3508100. 19: Hasegawa A, Ikeda I, Kawaguchi S. Color and translucency of in vivo natural central incisors. J Prosthet Dent. 2000 Apr;83(4):418-23. PubMed PMID: 10756291. 20: Okubo SR, Kanawati A, Richards MW, Childress S. Evaluation of visual and instrument shade matching. J Prosthet Dent. 1998 Dec;80(6):642-8. PubMed PMID: 9830067.