3M-003 | CAS# 162397-26-4 | TLR7/8 Agonist

MedKoo Cat#: 564020 | Name: 3M-003

Description:

WARNING: This product is for research use only, not for human or veterinary use.

3M-003 is a potent TLR7/8 agonist that induces robust production of the Th1-polarizing cytokines TNF-alpha and IL-12 from neonatal antigen-presenting cells (APCs).

Chemical Structure

3M-003

CAS#162397-26-4

Theoretical Analysis

MedKoo Cat#: 564020

Name: 3M-003

CAS#: 162397-26-4

Chemical Formula: C17H26N4O2

Exact Mass: 318.2056

Molecular Weight: 318.42

Elemental Analysis: C, 64.12; H, 8.23; N, 17.60; O, 10.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

3M-003; 3M003; 3M 003

IUPAC/Chemical Name

1-(4-Amino-2-(ethoxymethyl)-6,7,8,9-tetrahydro-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol

InChi Key

JGPXFNFCEPOWRD-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H26N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h22H,4-10H2,1-3H3,(H2,18,19)

SMILES Code

CC(O)(C)CN1C(COCC)=NC2=C1C3=C(N=C2N)CCCC3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 318.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Brummer E, Antonysamy MA, Bythadka L, Gullikson GW, Stevens DA. Effect of 3M-003, an imidazoquinoline, on phagocyte candidacidal activity directly and via induction of peripheral blood mononuclear cell cytokines. FEMS Immunol Med Microbiol. 2010 Jun 1;59(1):81-9. doi: 10.1111/j.1574-695X.2010.00664.x. Epub 2010 Feb 22. PubMed PMID: 20337703. 2: Hanten JA, Vasilakos JP, Riter CL, Neys L, Lipson KE, Alkan SS, Birmachu W. Comparison of human B cell activation by TLR7 and TLR9 agonists. BMC Immunol. 2008 Jul 24;9:39. doi: 10.1186/1471-2172-9-39. PubMed PMID: 18652679; PubMed Central PMCID: PMC2503978.